CONTEXT Strontium ranelate reduces vertebral and nonvertebral fracture risk in postmenopausal osteoporosis. OBJECTIVE The objective of this study was to determine the efficacy and safety of strontium ranelate in osteoporosis in men over 2 years (main analysis after 1 year). DESIGN This was an international, unbalanced (2:1), double-blind, randomized placebo-controlled trial (MALEO [MALE Ost...

CONTEXT The Women's Health Initiative Memory Study (WHIMS) previously found increased risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA). OBJECTIVE To determine the effects of CEE alone and CEE plus MPA on incidence of probable dementia and MCI in older women. DESIGN, SETTING, AND ...

BACKGROUND A more profound investigation of respiratory muscle strength during COPD exacerbation was needed, so we investigated respiratory muscle strength and related factors in patients with COPD during and after hospitalization for COPD exacerbation. METHODS In 19 subjects hospitalized for COPD exacerbation (12 males, mean age 67 ± 11 y, median percent-of-predicted FEV(1) 26% [IQR 19-32%])...

Patients with Atypical Anorexia Nervosa (AAN) have all the features of (AN) but are normal or above weight. Limited data on course and outcome exist in AAN. Purpose: To compare weight gain psychological recovery patients AAN AN. This is a secondary analysis from Study Refeeding to Optimize Inpatient Gains (StRONG) trial, multicenter randomized controlled trial comparing higher-calorie refeeding...

Abstract Introduction It has been documented that newborn’s sleep is strongly associated with maternal and paternal sleep. However, mothers seem to be more affected by their infant’s than fathers. These associations are not well known in families of premature newborns yet. This was the objective present study. Methods 30 (mothers, fathers infants) participated this study one month after dischar...

Green tea is rich in polyphenolic antioxidants and has widely reported but largely unsubstantiated health benefits. In the present study, genoprotective effects of two types of green tea were studied both in an in vitro and in a human supplementation trial. For the in vitro study, human lymphocytes were pre-incubated in tea (0·005-0·1 %, w/v), washed and subjected to oxidant challenge induced b...

Abstract Study question Is there an association between advancing male age and worsening seminal parameters (If so, is it possible to define age-threshold for semen quality decline)? Summary answer Only sperm morphology motility-related exhibited a significant negative with age, particularly from the of 40 years. What known already While importance advanced maternal on reduced fertility higher ...

The standard of care for primary central nervous system lymphoma (PCNSL) is systemic chemotherapy with or without whole brain radiotherapy or intrathecal chemotherapy. In contrast to treatment for other brain tumors, efforts at resection are discouraged. This is a secondary analysis of the German PCNSL Study Group-1 trial, a large randomized phase III study comprising 526 patients with PCNSL. P...