Developing N-heterocyclic carbene (NHC) chemistry of simple organomagnesium compounds, this study reports the synthesis, X-ray crystallographic, and NMR spectroscopic characterization of three such new carbene complexes. The 1 : 1 alkyl magnesium amide : carbene complexes nBuMg(TMP)·IPr 1 and nBuMg(HMDS)·IPr 2 both exist as mononuclear complexes in the crystal but differ in solution as 2 remain...

Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10-15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of dysmyelopoiesis and sometimes abnormal karyotype. Laboratory and clinical evidence suggest that HMDS share several immune-mediated pathogenic mechanisms with acquired idiopath...

Microwave irradiation (MWI) has been applied to the development of rapid methods to process biological samples for scanning electron microscopy (SEM). In this paper we propose two simple and quick techniques for processing bacteria (Proteus mirabilis and Vibrio mimicus) for SEM using MWI. In the simplest methodology, the bacteria were placed on a cover-glass, air-dried, and submitted to conduct...

The use of virtual environments with head-mounted displays (HMDs) offers unique assets to the evaluation and therapy of clinical populations. However, research examining the effects of this technology on clinical populations is sparse. Understanding how wearers interact with the HMD is vital. Discomfort leads to altered use of the HMD that could confound performance measures; the very measures ...

In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells. We analyzed patients with AA (N 93) and hypocellular MDS (hMDS, N 24) using single nucleotide polymorphism arrays (SNP-A) complementing routine cyto...

Electron paramagnetic resonance (EPR) spectroscopy is widely used to study free radicals or paramagnetic centers associated with biopolymers. With the advent of pulsed EPR methods, which allow accurate distance measurements between 20 and 80 , structures of biopolymers have increasingly been interrogated by this technique. Some of the advantages of EPR spectroscopy over other structural techniq...

We report measurements of the state of wetting of two liquid mixtures at coexistence near their respective critical consolute temperatures. Borosilicate glass capillary tubes were reacted with hexamethyldisilazane to produce substrates of uniform and controlled silylation. Surfaces of low coverage exhibit a series of first-order partial to complete wetting transitions and obey a short-range for...

Flavobacterium columnare is the causative agent of the columnaris disease, which is recognized as one of the main pathogens of fresh water fishes. Early studies [1] indicated that F. columnare presents a broad genetic heterogeneity within the species, and isolates can be classified into three different genomovars based on the 16S rDNA gene restriction fragment length polymorphisms (16S rDNA-RFL...

The microelectronics industry is increasingly looking towards high resolution lithographic techniques, such as electron beam (E-Beam) and extreme ultraviolet (EUV) lithography, in order to fabricate sub 100 nm features. Complimentary to this field of research is the design and evaluation of new photoresists to enable such processes. Molecular glass resists are possible candidates for this appli...

Detecting psychiatric disorders of secondary origin is a crucial concern for the psychiatrist. But how can this reliably be done among a large number of conditions, most of which have a very low prevalence? Metabolic screening undertaken in a population of subjects with psychosis demonstrated the presence of treatable metabolic disorders in a significant number of cases. The nature of the sympt...