BACKGROUND As obesity increases, the frequency of obstructive sleep apnea and obesity hypoventilation syndrome increases also. However, obesity hypoventilation syndrome frequency is not known, as capnography and arterial blood gas analysis are not routinely performed in sleep laboratories. AIMS To investigate the frequency and predictors of obesity hypoventilation syndrome in obese subjects. ...

Desaturation of [1-r4C]stearic acid, [lJ4C]palmitic acid, and [l-14C]stearoyl-CoA was measured in homogenates of lo-day-old rat brain. Desaturation was maximal with stearoyl-CoA at pH 6.0 to 6.6. With free fatty acids, monoene formation was maximal at pH 7.2 to 7.6; stearic acid was more actively desaturated than palmitic acid. Activity with stearic acid or stearoyl-CoA was linear with protein ...

BACKGROUND Desaturation occurs for many reasons under anaesthesia, some rare and obscure, and many potentially life threatening. The rapidity with which the cause is determined and appropriate management is instituted varies considerably between anaesthetists. OBJECTIVES To examine the role of a previously described "core" algorithm COVER ABCD-A SWIFT CHECK, supplemented by a specific sub-alg...

Interest in the causes and characteristics of chronic obstructive pulmonary disease (COPD) and its clinical manifestations has grown in the last 10 years. The range of clinical symptoms and other specific characteristics of COPD patients has led it be considered more as a syndrome than a disease, and many investigators have been motivated to define new phenotypes that reflect the particular fea...

To examine the relationship between sleep-disordered breathing (SDB) and blood pressure levels among Japanese men, we conducted a population-based cross-sectional study of 1,424 men aged 40-69 years in rural and urban communities. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB, representing the number of desaturation events per hour of recording time in which blood ...

In a group of 37 heavy snorers with obstructive sleep apnoea (OSA, Group 1) and a group of 23 heavy snorers without OSA (Group 2) cephalometric indices, ENT indices related to upper airway collapsibility, and nocturnal O2 desaturation indices were related to variables from maximal expiratory and inspiratory flow-volume (MEFV and MIFV) curves. The cephalometric indices used were the length and d...

STUDY OBJECTIVES To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins. DESIGN AND SETTING A biometric genetic study based on data from unattended Edentrace recordings in a sample of elderly male twins. PARTICIPANTS 122 World War II male veteran twin pairs, including 68 monozygotic pairs aged 78.9 (...

The risk of cardiovascular complications is increased in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the most effective way to treat clinically significant OSA. We hypothesized that the concentrations of the cardiac risk markers N-terminal brain natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TropT) correlate with the effectivenes...

BACKGROUND The relationship between sleep and mood regulation is well known, and some reports suggest a key role of sleep-related breathing disorders (SRBD) in the development of the symptomatology of depression, even if no conclusive data are actually found in the clinical literature. The aim of this study was to assess the relationship between SRBD and depressive symptoms in a population of s...

In patients with fibrotic idiopathic interstitial pneumonia (f-IIP), the diffusing capacity for carbon monoxide (DLCO) has been used to predict abnormal gas exchange in the lung. However, abnormal values for arterial blood gases during exercise are likely to be the most sensitive manifestations of lung disease. The aim of this study was to compare DLCO, resting PaO(2), P(A-a)O(2) at cardiopulmo...