An efficient one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines in good yield and under mild reaction conditions is described. By exploiting electron-deficient hydroxylamines, the substituted oxime products were formed with very high E-diastereoselectivity. The key step utilizes a cyclization reaction upon an oxime derived from hydroxylamine-O-sulfonic acid to form the N-N bond of the product.

Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.

Oxime carbonates were found to be excellent precursors for the clean and direct generation of iminyl radicals under UV irradiation. Suitably functionalised iminyls underwent cyclisations yielding various phenanthridines and also substituted quinolines and isoquinolines. EPR and X-ray analyses of oxime carbonates provided insight into the mechanism.

Binding to plasma proteins is one of the major metabolic pathways of metallodrugs. In the case of platinum-based anticancer drugs, it is the interaction with serum albumin that affects most strongly their in vivo behavior. Since both the configuration, i.e. cis-trans-isomerism, and the nature of leaving groups have an effect on the reactivity of Pt(II) coordination compounds toward biomolecules...

The synthesis of functionalized polyolefins through coordination–insertion polymerization is a highly challenging reaction. ideal catalyst, in addition to showing high productivity, has be able control the copolymer microstructure and, particular, way polar vinyl monomer incorporation. In this contribution, we modified typical Brookhart’s catalyst by introducing fourth coordination site palladi...

The use of phenyl-2-pyridyl ketone oxime and di-2-pyridyl ketone oxime in Mn chemistry has led to hexanuclear clusters with unprecedented (Mn(II)(4)Mn(III)Mn(IV)) or extremely rare (Mn(II)Mn(III)(5) and Mn(II)(3)Mn(III)(3)) metal oxidation-state combinations and uncommon structural motifs.

In the title compound, C(9)H(11)NO(3), the oxime grouping is twisted by 12.68 (6)° with respect to the dimethoxyl-benzene ring. In the crystal, mol-ecules are linked into an infinite [100] chain via O-H⋯N hydrogen bonds, instead of the more common oxime packing motif of dimers with an R(2) (2)(6) graph-set motif.

Carbon nanotube electrodes were modified with ferrocene and laccase using two different click reactions strategies taking advantage of bifunctional dendrimers cyclopeptides. Using diazonium functionalization the efficiency oxime ligation, combination both multiwalled carbon surfaces or cyclopeptides allows access to a high surface coverage in order 50 nmol cm–2, 50-fold increase compared classi...