Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...

BACKGROUND Oxidative stress generated within inflammatory joints can produce autoimmune phenomena and joint destruction. Radical species with oxidative activity, including reactive nitrogen species, represent mediators of inflammation and cartilage damage. OBJECTIVES To assess serum nitric oxide as a marker of oxidative stress in Egyptian patients with rheumatoid arthritis and its relation to...

A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide exhibited interesting antichagasic activity on the two parasitic strains and the two parasitic stages evaluated. Furthermore, besides its trypanocidal activity, 3-cyano-2-(4-nitrophenyl)-2H-indazole N1-oxide showed leishmanoci...

Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some antican...

Cystic fibrosis affects multiple organs but lung disease remains the major determinant of patient morbidity and mortality. Cystic fibrosis lung disease is characterized by chronic infection and inflammation. The amino acid L-arginine is substrate for both nitric oxide synthases and arginases. The activity of arginase in sputum is increased while the production of nitric oxide is reduced in the ...

Recently, arginase is suggested to regulate nitric oxide production by competing with nitric oxide synthase for the same substrate, L-arginine, in experimental asthma. We investigated the role of arginase and its relationship to nitric oxide production after spinal cord injury. Rats were subjected to laminectomy and complete transection of their spinal cords (injury group) or laminectomy only (...

A series of metal oxides were deposited on the surface of different oxide supports to study the surface oxide support interactions. The dehydrated Raman spectra of the supported metal oxide catalysts reveal the presence and structure of the supported metal oxide phases. The same surface metal oxide species were found on the different oxide supports for each of the supported metal oxide systems....

The effect of halothane and nitrous oxide on the capacity of natural killer (NK) lymphocytes from female patients with benign and malignant breast disease to kill the tumour cell line K562, was studied in vitro. There was no depression of activity of NK lymphocytes when exposed to 2% halothane and 66% nitrous oxide either alone or in combination. However, NK lymphocyte activity was depressed at...

The increase in blood flow evoked by synaptic activity is essential for normal brain function and underlies functional brain imaging signals. Nitric oxide, a vasodilator released by NMDA receptor activation, is critical for the flow increase, but the factors linking NMDA receptor activity to nitric oxide-dependent hyperemia are poorly understood. Here, we show that tissue plasminogen activator ...

Zinc oxide nanowire photoanodes are chemically stabilized by conformal growth of an ultrathin shell of titania through atomic layer deposition, permitting their stable operation for water splitting in a strongly alkaline solution. Because of the passivation of zinc oxide surface charge traps by titania coating, core/shell nanowire arrays supply a photocurrent density of 0.5 mA/cm under simulate...