background: in this study, the toxicity of the different xenobiotics was tested on the fruit fly drosophila melanogaster model system.  methods: fly larvae were raised on food supplemented with xenobioticsat different concentrations (sodium nitroprusside (0.1-1.5 mm), s-nitrosoglutathione (0.5-4 mm), and potassium ferrocyanide (1 mm)). emergence of flies, food intake by larvae, and pupation hei...

introduction: recently depleted uranium is being widely used as anti-armour ammunition and at very high temperature, results in information of an aerosol of very small uranium oxide particles, which may be inhaled. it is alleged that these particles represent a new battlefield hazard because of the chemical toxicology and/or radioactivity. method & materials: male wistar strain albino rats were...

objective (s): there is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. gamma oryzanol (go) is one of the major bioactive components in rice bran has been considered to function as an antioxidant. the present study was carried out to evaluate the antioxidant activity of gamma oryzanol in vitro and its effica...

objective(s) there are some reports in recent years indicating that renal ischemia - reperfusion (ir) induces deleterious changes in remote organs such as liver. the aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal ir. materials and methods inbred mice in ir donor group were subjected to renal ir injury. in sham donor ...

introduction: the therapeutic potential of anandamide (aea) for the neurological disorders may be negatively affected by its short half-life or poor solubility. the superior properties of carbon nanotubes (cnts) for controlled drug delivery, prompted us to design aea-cnts complex and assess its effect in in vitro model of ischemic stroke. methods: in this experimental study, a multi-walled cnts...

diabetes is one of the most common metabolic disorders and is interrelated to oxidative stress-induced diseases. according to the role of dietary antioxidants in control and prevention of diabetes, this study was aimed to evaluate the effect of green tea extract on serum glucose levels and serum and hepatic total antioxidant capacity (tac) and lipid (mda) in diabetic rats. experimental diabetes...

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background: the early stage of copper poisoning is difficult to be clinically diagnosed in sheep and has not been documented clearly yet. objectives: to assess biomarkers in predicting early copper poisoning in sheep, blood samples were collected from several groups of animals from a naturally copper poisoning occurrence in an industrial region. methods: animals were divided into four experimen...

anaplasma ovis infections can cause severe anemia in the acute phase of the disease. in order to investigate the alterations of erythrocyte protective antioxidant mechanisms associated with anemia in sheep experimentally infected with a. ovis, 100 ml heparinized blood was collected from splenectomised sheep that showed 6% a. ovis parasitemia. inoculums of 20 ml blood were administered intraveno...

objective: one of the most significant damages to the genetic material is oxidative deamination of dna and free nucleotides in the cell pool. incorporation of deaminated purine nucleotides such as inosine triphosphate (itp, ditp) into the dna can increase the frequency of base substitution mutation. it has been suggested that presence and accumulation of these rough nucleotides can lead to gene...