Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of the voltage-gated sodium channel. It is closely related to both carbamazepine and oxcarbazepine. Eslicarbazepine has similar affinity to inactivated sodium channels (channels in just activated neurons) as carbamazepine, and greater efficacy in animal models of seizure than oxcarbazepine. In human pla...

Trigeminal neuralgia (TN) is a highly disabling disorder characterized by very severe, brief, electric shocks, like recurrent episodes of facial pain. New diagnostic criteria classifying TN on the basis presence trigeminal neurovascular conflict or an underlying neurological can help better characterize patients and determine treatments. Magnetic resonance imaging using specific sequences shoul...

CONTEXT In 2008, the US Food and Drug Administration mandated warning labeling for anticonvulsant medications regarding the increased risk of suicidal thoughts and behaviors. The decision was based on a meta-analysis not sufficiently large to investigate individual drugs. OBJECTIVE To evaluate the risk of suicidal acts and combined suicidal acts or violent death associated with individual ant...

Epilepsy is a very common neurological disorder with high prevalence and incidence. Several conventional antiepileptic drugs are being used for the treatment of various types of epilepsies. Over the last two decades, there has been a rapid expansion in the number and types of available antiepileptic drugs (AED). Newer AEDs are now available for the treatment of various forms of epilepsies. Lamo...