نتایج جستجو برای: oxazolidinone antibiotic

تعداد نتایج: 82349  

Journal: :Chemical & pharmaceutical bulletin 2014
Deepak Bhattarai Ju-hyeon Lee Seon Hee Seo Ghilsoo Nam Hyunah Choo Soon Bang Kang Jin-Hwan Kwak Taegwon Oh Sang-Nae Cho Ae Nim Pae Eunice Eunkyeong Kim Nakcheol Jeong Gyochang Keum

A novel series of oxazolidinone-class antimicrobial agents with 5-substituted octahydrocyclopenta[c]pyrrole moieties at the C-ring of linezolid and an acetamide or 1,2,3-triazole ring as the C-5 side chain of the oxazolidinone ring were prepared. The resulting series of compounds were evaluated for in vitro antimicrobial activity against Mycobacterium tuberculosis and a panel of clinically impo...

Journal: :Biological chemistry 2013
Jagmohan S Saini Nadine Homeyer Simone Fulle Holger Gohlke

Oxazolidinone antibiotics bind to the highly conserved peptidyl transferase center in the ribosome. For developing selective antibiotics, a profound understanding of the selectivity determinants is required. We have performed for the first time technically challenging molecular dynamics simulations in combination with molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) free energy calc...

2014
Pavan K. Kancharla Takayuki Kato David Crich

A method for the investigation of the influence of protecting groups on the anomeric equilibrium in the sialic acid glycosides has been developed on the basis of the equilibration of O-sialyl hydroxylamines by reversible homolytic scission of the glycosidic bond following the dictates of the Fischer-Ingold persistent radical effect. It is found that a trans-fused 4O,5N-oxazolidinone group stabi...

Journal: :Antimicrobial agents and chemotherapy 2002
D Andes M L van Ogtrop J Peng W A Craig

Linezolid is a new oxazolidinone with activity against gram-positive cocci. We determined the in vivo activity of linezolid against four strains of Staphylococcus aureus (two methicillin-susceptible S. aureus [MSSA] strains and two methicillin-resistant S. aureus strains) and one penicillin-susceptible Streptococcus pneumoniae (PSSP) strain, two penicillin-intermediate S. pneumoniae strains, an...

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