A new synthetic method for chiral oxazolidinone derivatives, therapeutic agents for treating urinary disturbance, is described. The condensed compound obtained from chiral 1-amino-3-phenyl-2-propanol and 1-phenyl-3-morpholino-1-propanone was reduced with Me4NBH(OAc)3 to give the intermediate, 1-(3-morpholino-1-phenylpropyl)amino-3-phenyl-2-propanol (MAPP) in 34% diastereomeric excess (d.e.). MA...

[Electronic Supplementary Information to accompany Chem. Sci. MS# SC-EDG-09-2014-002785] Intramolecular ring-opening from a CO2-derived nucleophile as the origin of selectivity for 5-substituted oxazolidinone from the (salen)Cr-catalyzed [aziridine + CO2] coupling Debashis Adhikari, Aaron W. Miller, Mu-Hyun Baik,* SonBinh T. Nguyen* Department of Chemistry and the Institute for Catalysis in Ene...

The preparation of new, enantiomerically pure, α-amino acids from easily available starting materials is an ongoing challenge in synthetic organic chemistry. Here, we describe the syntheses and crystal structures three chiral oxazolidinone derivatives prepared L-alanine pivalaldehyde to form a Schiff base intermediate then reaction with appropriate acid chloride heterocycle. In each compound, m...

The sigma-2 (σ2) receptor, also known as the Transmembrane Protein 97 (TMEM97, and MAC30 (Meningioma-associated protein), has been linked to a number of conditions are disease states such schizophrenia, cancer, Alzheimer’s disease, traumatic brain injury, neuropathic pain. As part or our on-going effort identify novel σ2 ligands, we have identified series novel, functionalized oxazolidin-2-one ...