BACKGROUND Patients with transfusional iron overload may develop a life-limiting cardiomyopathy. The sensitivity of lipid-metabolizing enzymes to peroxidative injury, as well as the reported effects of arachidonic acid (AA) and metabolites on cardiac rhythm, led us to hypothesize that iron-overloaded cardiomyocytes display alterations in the release of AA and prostaglandins. METHODS AND RESUL...

In order to meet their temporal constraints, current distributed applications such as Web-based services and electronic commerce use the technique of data replication. To take the replication benefit, we need to develop concurrency control mechanisms with high performance even when the distributed system is overloaded. In this paper, we present a protocol that uses a new notion called importanc...

The water carrying capacity and the state are two similar concepts, there no clear boundaries between them, so exists confusion during evaluation process. Additionally, current methods cannot meet dynamic change requirements under different control measures. This study emphasizes difference concepts points out that core of is determination thresholds. In contrast, a evaluation. A coupled iterat...

Pressure-overloaded myocardial hypertrophy is an independent risk factor for various cardiovascular diseases (CVDs), such as heart failure (HF), arrhythmia, and even sudden death. It reported that QiShenYiQi pill (QSYQ) widely used in the treatment of CVDs can prevent pathological myocardium, but its specific mechanism still unclear. In this study, a rat model was established through pressure o...

Skeletal-muscle (both respiratory and limb) abnormalities are common and can have profound effects in patients with chronic inflammatory states such as chronic obstructive pulmonary disease (COPD). Causes include direct inflammatory-mediator effects on muscle function, malnutrition, blood-gas abnormalities, compromised oxygen delivery from right-heart dysfunction, electrolyte imbalances, drugs,...

Existing parallel file systems are unable to provide both throughput and response time guarantees for concurrent parallel applications. This limitation prevents different, competing applications from getting their desired performance as high-performance computing (HPC) systems continue to scale up and be used in a shared environment. This paper presents a new two-level scheduler for parallel st...

Three different strategies are identified for organizational adaptation, including dynamic process selection. An executable organizational model composed of individual models of a five stage interacting decision maker is used to evaluate the effectiveness of the different adaptation strategies on organizational performance. The concept of entropy is used to calculate the total activity value, a...

Time constraint is the main factor in real time operating system. Different scheduling algorithm is used to schedule the task. The Earliest Deadline First and Ant Colony Optimization is a dynamic scheduling algorithm used in a real time system and it is most beneficial scheduling algorithm for single processor real-time operating systems when the systems are preemptive and under loaded. The mai...

The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth of coagulase-positive Staphylococcus aureus. Accordingly, we tested whether deferiprone, a new clinically-available iron-chelator, can prevent the growth of S. aureu...

An object-oriented MATLAB system is described for performing numerical linear algebra on continuous functions and operators rather than the usual discrete vectors and matrices. About eighty MATLAB functions from plot and sum to svd and cond have been overloaded so that one can work with our “chebfun” objects using almost exactly the usual MATLAB syntax. All functions live on [−1, 1] and are rep...