Opioid overdose rates have increased in the United States over past decade and reflect a major public health crisis. Modeling prediction of drug opioid hotspots, where high percentage events fall small space–time, could help better focus limited social services. In this work we present spatial-temporal point process model for clustering. The data input into comes from two heterogeneous sources:...

A trend in the increasing use of prescription psychoactive drugs (PADs), including antidepressants, antipsychotics, and mood stabilizers, has been reported United States globally. In addition, there an increase production usage illicit PADs emergence new substances (NPSs) all over world. pose unique challenges for critical care providers who may encounter toxicology issues due to drug interacti...

BACKGROUND To determine the existence of a social gradient in fatal overdose cases related to non-prescribed opioids and cocaine use, recorded in Luxembourg between 1994 and 2011. METHODS Overdose cases were individually matched with four controls in a nested case-control study design, according to sex, year of birth, drug administration route and duration of drug use. The study sample, compo...

Septicaemia occurred after accidental oral overdoses of iron in two previously healthy children. Yersinia enterocolitica serotype 0:3 was recovered from blood and stool cultures in both patients. Enhanced growth of Y enterocolitica in the intestine combined with damage of intestinal mucosa may have been of major importance for the development of generalised infection in these cases. Iron and th...

Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycem...