OBJECTIVE To analyze the effects of physical exercise on cartilage histomorphometry in osteoporosis-induced rats subjected to immobilization. METHODS We used 36 Wistar rats that were separated into six groups: G1, G2 and G3 submitted to pseudo-oophorectomy, and G4, G5 and G6 submitted to oophorectomy. After 60 days at rest, G2, G3, G5 and G6 had the right hind limbs immobilized for 15 days, f...

Nekooeian, Ali Akbar, and Catherine C. Y. Pang. Effects of estrogen on venous function in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 278: H1941– H1947, 2000.—The effect of 17b-estradiol on venous function was investigated in ovariectomized rats with heart failure. Rats (50–60 days old) were ovariectomized and implanted with 60-day-release pellets that contain 17b-estradiol...

Chronic estrogen replacement in ovariectomized rats attenuates food intake and enhances c-Fos expression in the suprachiasmatic nucleus (SCN), specifically during the light phase. S-equol, a metabolite of daidzein, has a strong affinity for estrogen receptor (ER)-β and exerts estrogenic activity. The purpose of the present study was to elucidate whether S-equol exerts an estrogen-like anorectic...

objective(s): the present study aims at examining the motor coordination performance, serum and cerebellar estrogen, as well as erβ levels, of ovariectomized rats (as menopausal model) following regular exercise. materials and methods:ten female sprague dawley ratsaged 12 weeks old were randomly divided into two groups; all of which underwent ovariectomy. the first group was treated with regula...

Intestinal calcium (Ca) absorption was measured under noninvasive conditions in both normally cycling and ovariectomized rats by determining the decrease in 47Ca/47Sc ratio between diet and feces. In 32-wk-old rats fed a 1.4% Ca diet, both fractional and total intestinal Ca absorption varied during the estrous cycle (p < 0.03), being highest during estrus and lowest during the second day of die...

We reported that ginger prevented obesity in mice fed a high-fat diet in previous study. In this experiment, we examined the effects of zingerone, the major pungent component of ginger on fat storage in ovariectomized (Ovx) rats. Oral administration of 170 mg/kg zingerone significantly reduced body weight and the final parametrail adipose tissue weight in ovariectomized rats. Blood glucose leve...

Introduction : Peptic ulcer occurs more frequently in men than in women, sex differences are less marked after 45 years of age probably because the incidence of ulcer increases in post menopausal women. The general assumption is that the ulcer differences between sexes are related in some way to sex hormones and that the female sex hormones protect against ulceration. The aim of the this study ...

Both known estrogen receptors, ERalpha and ERbeta, are expressed in blood vessels. To gain further insight into the role of ERalpha in a functional setting, we investigated the effect of the novel highly selective ERalpha agonist Cpd1471 on vascular reactivity in ovariectomized spontaneously hypertensive rats (SHR). After ovariectomy or sham operation, 12-week-old female SHR received either 17b...

The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercis...

BACKGROUND The effects of estrogene on central nervous system are still controversial. OBJECTIVE We aimed to investigate the effects of raloxifene on the antioxidant enzyme [superoxide dismutase (SOD) and catalase (CAT)] activities and malondialdehyde (MDA) levels in brain homogenates of ovariectomized female rats and its effect on cognitive process of learning. MATERIALS AND METHODS Female...