background: the main part of ovary is consisted of follicles which certain drugs may cause change in them. objectives: the purpose of this study was to investigate the effects of methylphenidate on ovarian follicle of mice, treated by ritalin before puberty. methods: 40 immature female mice at 3 weeks of age were divided into 4 groups, consisting of one control and 3 experimental groups. the ex...

Objective In the present study, the effects of alginate (ALG) concentration and ovarian cells (OCs) on the development and function of follicles were simultaneously evaluated. MaterialsAndMethods In the first step, preantral follicles (100-130 µm in diameter) were mechanically isolated from the ovaries of 2-week-old NMRI mice, encapsulated in the absence or presence of OCs in 0.5, 0.75 and 1% A...

This study carried out to understand the effects of Potassium Dichromate (K2Cr2O7) and Turmeric Oil (TO) on reproductive efficiency. Twenty four weanling immature female albino rats aged 22 day divided randomly into 4 groups (6 rats in each group). 1 group received 0.1 ml dimethyle sulfoxide (DMSO) 5% solution as a control (I/P for 14 day), 2 group received K2Cr2O7 dissolved in distilled water ...

Although hormonal regulation of ovarian follicle development has been extensively investigated, most studies concentrate on the development of early antral follicles to the preovulatory stage, leading to the successful use of exogenous FSH for infertility treatment. Accumulating data indicate that preantral follicles are under stringent regulation by FSH and local intraovarian factors, thus pro...

BACKGROUND The growth pattern of the smallest ovarian follicles in humans is still incompletely documented. Using follicle hemispheres in thick histological sections, morphometric changes of primordial to primary follicles and possible age-related effects were evaluated. METHODS In ovarian sections from 25 females aged 4-39 years a total of 1122 primordial, transitory or primary follicles wer...

It was long believed that mammals are born with a fixed number of primordial follicles, each of which encloses an oocyte arrested at the diplotene step of meiotic prophase. Arising at or after birth, small numbers of primordial follicles become activated each day and enter a folliculogenic growth phase during which follicles either degenerate by atresia or complete maturation, resulting in ovul...

BACKGROUND Little is known about the factors that control the initiation of growth of primordial follicles. Primordial follicles in pieces of fetal bovine ovarian cortex spontaneously activate in vitro and develop to the primary stage, but few follicles develop further. For decades, embryologists have grafted tissue to the chorioallantoic membrane (CAM) of chick embryos to study the development...

BACKGROUND Lysophosphatidic acid (LPA) regulates reproductive processes in the cow. Ovarian granulosa cells play a pivotal role in follicle growth and development. Nevertheless, the role of LPA in the local regulation of granulosa cell function in different follicle categories in the bovine ovary has not been investigated. METHODS Ovarian follicles were divided into healthy, transitional and ...