Clinically useful drugs target a relatively small number of proteins that lie within a clearly defined and chemically accessible space. However, many high value biological targets lie outside this chemical space, and an ability to access such 'intractable' targets not amenable to traditional small molecule intervention would expand treatment options and be a major boost for patients and the pha...

This paper challenges the idea of creating an architectural approach for designing a complex hybrid cognitive agent, i.e. an agent which possesses all reactive, deliberative and affective capabilities, outside the hierarchical paradigm. Thus, it presents an agent architecture based on Marvin Minsky’s “Society of Mind” (SoM) metaphor on human mind and cognition and shows how SoM agents, through ...

The RoboCup Rescue Simulation League aims to benchmark the intelligence of software agents and robots on their capabilities to make autonomously the right decisions in a disaster response scenario. The UvA Rescue and Distribot team have come together to work cooperatively to support this aim in two ways. One aspect is to advance the popularity of this League by presenting the background of the ...

In this paper we present an Agent-based Open Service Architecture (OSA) which integrates geographically distributed agents in the Web. Agents can be realized with traditional AI techniques, but they also provide a set of Web Services to the outside world which constitute their capabilities. The architecture extends the Web with a facilitator level providing agents’ specific support. Moreover it...

The RoboCup Rescue Simulation League aims to benchmark the intelligence of software agents and robots on their capabilities to make autonomously the right decisions in a disaster response scenario. The UvA Rescue and Distribot team have come together to work cooperatively to support this aim in two ways. One aspect is to advance the popularity of this League by presenting the background of the ...

A frame design technique for use with vector selection algorithms, for example Matching Pursuits (MP), is presented. The design algorithm is iterative and requires a training set of signal vectors. The algorithm, called Method of Optimal Directions (MOD), is an improvement of the algorithm presented in [1]. The MOD is applied to speech and electrocardiogram (ECG) signals, and the designed frame...

The late 1990s saw a proliferation of technical and organisational advances in software engineering and in its application. For the software engineering manager these advances provide both a range of opportunities and a considerable challenge in defining a software strategy. That strategy must now include: linking the software organisation's work to corporate strategic priorities understanding ...

This paper proposes a model that suggests how firms could create strategic capabilities through IT outsourcing. We suggest how a firm adds value and reaps strategic benefits from IT outsourcing arrangements. A primary proposition is that, in the process of penetration of the managerial and technical capabilities of external vendors, managerial and social factors act as facilitators or inhibitor...

We consider a model of liquidity demand arising from a possible maturity mismatch between asset revenues and consumption. This liquidity demand can be met with either cash reserves (inside liquidity) or via asset sales for cash (outside liquidity). The question we address is, what determines the mix of inside and outside liquidity in equilibrium? An important source of inefficiency in our model...

We consider a model of liquidity demand arising from a possible maturity mismatch between asset revenues and consumption. This liquidity demand can be met with either cash reserves (inside liquidity) or via asset sales for cash (outside liquidity). The questions we address are: (a) what determines the mix of inside and outside liquidity in equilibrium? (b) does the market provide an efficient m...