Twelve healthy young volunteers were studied before and during intravenous administration of lidocaine at a dose rate of 2 or 4 mg/min. Five additional volunteers, who did not receive lidocaine solution but were given the same amount of physiological saline, were studied in the same manner. Heart rate, cardiac output, mean arterial blood pressure, mean right atrial blood pressure, estimated hep...

We injected neuroexcitatory and neuroinhibitory agents into the depressor region of the caudal ventrolateral medulla of anesthetized rabbits and determined the effect on arterial pressure, myocardial contractility, cardiac output, and plasma catecholamines and neuropeptide Y. Brief excitation of the sympathoinhibitory neurons with medullary injection of L-glutamate reduced arterial pressure, pe...

Abstract: This paper proposes an optimization based maximum power point tracking (MPPT) algorithm for selection of appropriate external rotor resistances of wound rotor induction generator (WRIG). The generator coupled with a Wells turbine is used in oscillating water column (OWC) wave power plants. The Wells turbine suffers with stalling behaviour that reduces the average output power signific...

Two primary predictor variables, age and supine plasma norepinephrine, were studied with respect to their influences on supine hemodynamic variables in 52 white men with essential hypertension who were 23 to 67 years of age and had been off active therapy for at least 4 weeks. Plasma norepinephrine was related to age (r = 0.39, p less than 0.01), correlated closely with mean arterial pressure (...

Simultaneous regional blood flow and resistance measurements were made in 21 organs in 11 supine unanesthetized rhesus monkeys before and during two different d ses of intravenously infused angiotensin II or saline. Systemic arterial pressure and total peripheral resistance significantly increased at both infusion rates in the six experimental monkeys, compared with changes in five control monk...

The cardiovascular effects of elevated cerebrospinal fluid (CSF) pressure were studied in 18 dogs, 6 in a control group, 6 after alpha adrenergic blockade, and 6 after beta adrenergic blockade. Vascular pressures did not change until CSF pressure was increased from 100 mm Hg to 200 mm Hg. In the control group, the aortic, pulmonary arterial, wedge, and right atrial pressures increased significa...

Kowalski and Abelmann originally described the hyperdynamic circulation associated with cirrhosis in 1953, which is characterised by an increased cardiac output, heart rate, and stroke volume and reduced peripheral vascular resistance [1]. The hyperdynamic circulation of cirrhosis is characterised by increased cardiac output and decreased systemic vascular resistance being independently associa...

Rats anesthetized with ethyl ether were compared with rats anesthetized with sodium pentobarbital from the standpoint of cardiac output, peripheral resistance and regional blood flow. Cardiac output was measured by the indicator-dilution technic; regional blood flow was determined by the indieator-fractionation technic employing Rb or I-antipyrine. The cardiac output is one and a half times as ...

This case series of 27 patients with large stroke challenges the current state of the art guiding hemodynamic management by blood pressure levels. The results show that assumed correlations of blood pressure, cardiac output, and systemic vascular resistance do not exist. Therefore, hemodynamic therapy may better be guided by cardiac output.