نتایج جستجو برای: outer hair cells

تعداد نتایج: 1459809  

Journal: :Biophysical journal 2005
David R Murdock Sergey A Ermilov Alexander A Spector Aleksander S Popel William E Brownell Bahman Anvari

An optical tweezers system was used to characterize the effects of chlorpromazine (CPZ) on the mechanical properties of the mammalian outer hair cell (OHC) through the formation of plasma membrane tethers. Such tethers exhibited force relaxation when held at a constant length for several minutes. We used a second-order generalized Kelvin body to model tether-force behavior from which several me...

Journal: :TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 1992

Journal: :Journal of the Association for Research in Otolaryngology 2011

Journal: :Micromachines 2023

Hair follicles play an important role in hair development. This study aimed to develop a microgel-spotting device fabricate multilayered gel bead culture model and mimic the early development of skin appendages regenerate vitro. The consists alginate layer containing cytokines as core layer, collagen mouse embryonic stem cells middle fetus-derived epidermal outer layer. A concentration gradient...

Journal: :Development 2000
J L Zheng J Shou F Guillemot R Kageyama W Q Gao

Hair cell fate determination in the inner ear has been shown to be controlled by specific genes. Recent loss-of-function and gain-of-function experiments have demonstrated that Math1, a mouse homolog of the Drosophila gene atonal, is essential for the production of hair cells. To identify genes that may interact with Math1 and inhibit hair cell differentiation, we have focused on Hes1, a mammal...

Journal: :British medical bulletin 2002
Jonathan Ashmore

Understanding how the cochlea works as a system has become increasingly important. We need to know this before integrating new information from genetic, physiological and clinical sources. This chapter will show how the cochlea should be seen as a device for carrying out a frequency analysis built from cells that have been adapted for specialist purposes. Sensory hair cells convert mechanical d...

Journal: :The Journal of the Acoustical Society of America 1986
S T Neely D O Kim

A linear, mathematical model of cochlear biomechanics is presented in this paper. In this model, active elements are essential for simulating the high sensitivity and sharp tuning characteristic of the mammalian cochlea. The active elements are intended to represent the motile action of outer hair cells; they are postulated to be mechanical force generators that are powered by electrochemical e...

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