Twelve children, ranging in age from 8.9 to 12.4 years, with histories of severe otitis media with effusion (OME) before age 3, were compared to age-matched cohorts in their ability to discriminate the frequency of tone pulses of 20-, 50-, and 200-msec duration. An adaptive procedure was used in combination with a two-alternative forced-choice paradigm to measure difference limens (DLs) for dig...

The first part of this thesis evaluates two different treatment strategies in tympanostomy tube associated otorrhea. The second explores the tentative relation between the appearance of otitis media with effusion and the immunological activity in the adenoid, focusing on Toll-like receptor (TLR) 4 and TLR7 along with the nitric oxide (NO) inducing enzymes eNOS and iNOS. The third part investiga...

BACKGROUND The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the effects of ventilation tubes in high-risk populations have, to our knowledge, n...

Otologic problems are infrequent in HIV patients. Authors present the case of chronic otitis media in the HIV infected child. The patient with significant hearing loss, and prolonged aural discharge, resistant to local and systemic antibiotic treatment was treated surgically. Mastoidectomy with myringoplasty was performed. The substantial hearing improvement has been obtained, ear discharge nev...

BACKGROUND Middle ear disease (otitis media) is common and frequently severe in Australian Aboriginal children. There have not been any recent large-scale surveys using clear definitions and a standardised middle ear assessment. The aim of the study was to determine the prevalence of middle ear disease (otitis media) in a high-risk population of young Aboriginal children from remote communities...

Introduction: In spite of the fact that acute otitis media is a systemic and symptomatic disease with sever otalgia, otitis media with effusion (OME) is an asymptomatic and silent disease. OME is the most common cause of conductive hearing loss in children and has adverse effects on speech development and cognitive skills. Results: Among 1001 children under study, 57 subjects (5.7%) were dia...

Weert HCPM. NHG standard otitis media acuta. (Guideline on acute otitis media of the Dutch College of General Practitioners.) Huisarts Wet 1990;33:242-5. 9 Hoberman A, Paradise JL, Burch DJ, Valinski WA, Hedrick JA, Aronovitz GH, et al. Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium for treatment of acute otitis media in childr...

To study allergic and immunologic incidence of secretory otitis media, histamine levels were investigated in 90 cases with middle ear effusion by means of the fluorometric assay . Histamine concentration in effusions were significantly higher than serum levels. Statistical analysis indicated that there was no differences between serous and mucoid effusions, nor between children and adults. Tymp...

The first Genome Wide Association Study (GWAS) of otitis media (OM) found evidence of association in the Western Australian Pregnancy Cohort (Raine) study, but lacked replication in an independent OM population. The aim of this study was to investigate association at these loci in our family-based sample of chronic otitis media with effusion and recurrent otitis media (COME/ROM). Autosomal SNPs...