UNLABELLED Ochratoxin A (OTA) is a toxic secondary metabolite of fungi belonging to the Aspergillus and Penicillium genera, its presence in human blood being the primary indicator of exposure. AIM In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders. MATERIAL AND METHODS The OTA was determined through the direct, competitive, so...

The aim of this study was to select wine yeast strains as biocontrol agents against fungal contaminants responsible for the accumulation of ochratoxin A (OTA) in grape and wine and to dissect the mechanism of OTA detoxification by a Saccharomyces cerevisiae strain (DISAABA1182), which had previously been reported to reduce OTA in a synthetic must. All of the yeast strains tested displayed an a...

Ochratoxin A (OTA) producing fungi are members of the genera Aspergillus and Penicillium. Nowadays, there are about 20 species accepted as OTA producers, which are distributed in three phylogenetically related but distinct groups of aspergilli of the subgenus Circumdati and only in two species of the subgenus Penicillium. At the moment, P. verrucosum and P. nordicum are the only OTA producing s...

Cocoa beans from several types of post harvest treatments were processed into cocoa butter, cocoa powder and chocolate spread using traditional processing techniques. OTA was analyzed in two hundred and sixteen (216) samples of cocoa and cocoa derived products using HPLC with fluorimetric detection. It was found that OTA content in cocoa nibs depended only on the state of cocoa pod and the time...

ABSTRACT: Ochratoxin A (OTA) continues to attract global attention concerning the hazard and impact on both human and animals based on its toxicity and occurrence. The International Agency for Research on Cancer (IARC) classifies it as possible carcinogen to human (group 2B). A total of 98 samples of dried fruits consisting of coconut, sour cherry, slices of peaches, quinces, and pineapple from...

Malignant blue nevus is rare, and a common blue nevus rarely needs a differential diagnosis from malignant melanoma. Although a melanocytic nevus with a satellite lesion is usually suggestive of a peripherally disseminating malignant melanoma, very few cases of blue nevus with satellite lesions have been reported thus far. To our knowledge, this is the seventh case of a blue nevus with satellit...

We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MP...

Ochratoxin A (OTA) is a widespread nephrotoxin excreted to a substantial degree via the kidney. We investigated whether [3H]OTA is reabsorbed from the tubular lumen along the nephron and thus recycles within the kidney. Superficial early proximal and early distal tubules of male Wistar rats were micropunctured in situ. Microinfusion of OTA into superficial nephrons showed that it was reabsorbed...

Aim. Secondary tumor rarely develops from epidermal nevus. We present a case of a metastasizing squamous cell carcinoma that developed in a solitary epidermal nevus. Case Report. An 82-years old Japanese female was presented with a red tumor on the left axilla. She reported that the tumor developed in a congenital epidermal nevus. A biopsy of the tumor showed that a well-differentiated squamous...

Ochratoxin A (OTA) has been shown to be a potent nephrotoxic, hepatotoxic, and teratogenic compound. In farm animals, the intake of feed contaminated with OTA affects animal health and productivity, and may result in the presence of OTA in the animal products. Strategies for the control of OTA in food products require early identification and elimination of contaminated commodities from the foo...