In response to mechanical and/or metabolic stress the myocardium undergoes structural remodeling involving cardiomyocyte hypertrophy and interstitial and perivascular fibrosis.1 Cardiomyocyte hypertrophy includes an increase in contractile and embryonic protein content, which appears largely on the activation of transcription of the corresponding cardiac genes that encode these proteins. Myocar...

Introduction: Recent studies point to the clinical and research efficacy of saliva as a respected diagnostic aid for observing Multiple Sclerosis. The objectives of this Hypothesis are to identify novel biomarkers recognized to Multiple Sclerosis in early stage in saliva and to determine if the levels of these markers correlate with level of these Cerebrospinal fluid and blood assays and urine ...

The extracellular matrix of the normal adult brain lacks expression of most of the adhesive glycoproteins that are known to promote cell attachment, and it has been thought that the malignant invasion of astrocytoma tumor is mediated primarily by remodeling of the matrix by the tumor cells. It has been reported, however, that normal brain neuropil does contain a protein(s) that promotes cell at...

To study the role of la,25-dihydroxyvitamin I), (calcitrici) in tumor promotion, we used JB6 C141.Sa cells, a mouse epidermal cell model of tumor promotion. The phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA) irreversibly induces anchorage-independent growth and (urnorigenicity in these cells. Since we previously showed (hat calcitrici does not transform these cells but inhibits their ...

Aim: The identification of cellular pathways in colorectal tumor biology is essential for early diagnosis, treatment, and post-treatment follow-up. Osteopontin an extracellular matrix protein that has regulatory physiological functions roles apoptosis, proliferation, adhesion, invasion, metastasis. In this study, we aimed to determine the prognostic predictive value osteopontin colon adenocarci...

Osteopontin (OPN) is a 33.7 kDa intrinsically disordered protein and a member of the SIBLING family of proteins. OPN is bearing a signal peptide for secretion into the extracellular space, where it exerts its main physiological function, the control of calcium biomineralization. It is often involved in tumorigenic processes influencing proliferation, migration and survival, as well as the adhes...

In this issue of Blood, Boyerinas and colleagues report about a novel mechanism of leukemia cell evasion from chemotherapy.

Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN). Microarray analysis of spinal cords from rats paralyzed by experimental ...

This study was designed to investigate the biological effects of fish collagen peptide (FCP) on human osteoblasts. Human osteoblasts were treated with 0.1% FCP, which was the optimal concentration confirmed by the increase in alkaline phosphatase activity. After one, three, five and seven days of culture, the number of FCP-treated cells increased significantly compared with untreated cells. In ...