PURPOSE To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score. METHODS The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren-Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ...

OBJECTIVE The reduction in the level of mental health, particularly depression is associated with outcome of treatment in patients with osteoarthritis (OA). There is no broader research into mental health or mental health care for OA patients. The purpose of the present study was to determine mental health and its relationship with some clinical and demographic factors among patients with OA. ...

OBJECTIVE Cumulative data suggest that central sensitization may contribute to pain in osteoarthritis (OA) and present with symptoms typically associated with neuropathic pain (NP). We evaluated the responses from focus group participants on the knee OA pain experience for pain descriptions that suggest NP. METHODS Focus group transcripts were analyzed by 2 independent assessors for unprompte...

Exercise is recommended as a first-line conservative intervention approach for osteoarthritis (OA). A wide range of exercise programs are available and scientific evidence is necessary for choosing the optimal strategy of treatment for each patient. The purpose of this review is to discuss the effectiveness of different types of exercise programs for OA based on trials, systematic reviews, and ...

OBJECTIVE Lack of osteophytes (atrophic form) has been shown to be a factor in the severity of hip osteoarthritis (OA). The aim of this study was to determine the epidemiological, radiological and biological differences between the hypertrophic and atrophic forms of hip osteoarthritis. METHODS 25 patients with symptomatic hip OA (ACR criteria) and classified as having an atrophic form of OA b...

BACKGROUND Recommendations state that acetaminophen should be used in preference to nonsteroidal anti-inflammatory drugs in the initial treatment of symptomatic osteoarthritis (OA) of the hip or knee, because of lesser toxicity and the pervasive belief that acetaminophen is not only effective in treating OA pain but is of equal analgesic efficacy as nonsteroidal anti-inflammatory drugs. METHO...

Patellofemoral (PF) osteoarthritis (OA) is a somewhat predominant illness, affecting up to 24% of women and 11% ofmen over the age of 55 years who suffer from symptomatic knee OA. The purposes of this narrative overview are tosummarize the present situation of patellofemoral arthroplasty (PFA) in the treatment of solitary PF-OA, and to givean account of the clinical results of...

Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. Objectives: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. Materials an...

Osteoarthritis (OA) is a chronic, progressive, degenerative disease that affects many joints and is the most common type of arthritis. OA is classified as idiopathic, or as secondary, owing to traumatic, congenital or medical causes. It is characterized by the progressive loss of hyaline cartilage leading to joint space narrowing, osteophyte formation and bony changes. Patients with OA typicall...

Introduction: Osteoarthritis(OA) knee cases are increasing day by and with no established cure of disease only palliative ( analgesics ) therapy is given.Platelet-rich plasma (PRP) injection aim at reducing the pain as well causing regeneration articular cartilage partially reversing process. Methods: 49 patients OA were given PRP followed up for a period 48 weeks . Western Ontario McMaster Uni...