نتایج جستجو برای: orthopoxvirus
تعداد نتایج: 519 فیلتر نتایج به سال:
5-(Dimethoxymethyl)-2‘-Deoxyuridine: A Novel Gem Diether Nucleoside with Anti-Orthopoxvirus Activity
Mpox is a disease caused by an Orthopoxvirus, first discovered in Denmark 1958 and presenting its epidemic outbreaks 1970. Currently, as of May 2022, numerous cases have been reported non-endemic countries, generating worldwide concern given the current pandemic SARS-CoV-2. To date, more than 85,142 3,768 Mexico, predominantly male population, specifically men who sex with those history HIV maj...
Monkeypox (MPXV) is a viral infectious disease, capable of transmitting from animals to humans. It zoonotic virus responsible for causing the and belongs same family (orthopoxvirus) as smallpox virus. The first case human monkeypox infection was recorded in 1970 town called Basankusu, Democratic Republic Congo. There have also been reports disease outbreak across West Africa. outside Africa 200...
Human disease likely attributable to variola virus (VARV), the etiologic agent of smallpox, has been reported in human populations for >2,000 years. VARV is unique among orthopoxviruses in that it is an exclusively human pathogen. Because VARV has a large, slowly evolving DNA genome, we were able to construct a robust phylogeny of VARV by analyzing concatenated single nucleotide polymorphisms (...
Despite worldwide eradication of naturally occurring variola virus, smallpox remains a potential threat to both civilian and military populations. New, safe smallpox vaccines are being developed, and there is an urgent need for methods to evaluate vaccine efficacy after immunization. Here we report the identification of an immunodominant HLA-A*0201-restricted epitope that is recognized by cytot...
Enzyme-linked immunosorbent assay, Western blot, and virus neutralization assays indicated that red colobus monkeys in Kibale National Park, western Uganda, had antibodies to a virus that was similar, but not identical, to known orthopoxviruses. The presence of a novel poxvirus in this endangered primate raises public health and conservation concerns.
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