a simple extremely fast and efficient approach for the synthesis of substituted indazole ingood to excellent yield catalyzed by using silica sulfuric acid (ssa) in dmso solvent at roomtemperature. this is solid state reaction have been attracting the synthetic organic chemist asthey provided enhance reaction rates, less environmental pollution, greater selectivity, cleanerproducts and manipulat...

a new dimeric orthopalladated complex was synthesized via reaction of 2,3-dimethoxy benzaldehyde oxime with palladium chloride and lithium chloride in methanol as solvent and sodium acetate as base at room temperature. the catalytic activity of this dimeric [pd{c6h2(-ch=noh)-(ome)2-2,3}(µ-cl)]2 complex as an efficient, air, and moisture tolerant catalyst was investigated in mizoroki–heck cross ...

Recently, studies on the construction of 3D terrain modeling and location accuracy evaluation using UAV have been conducted, but application to coastal areas lacking image matching points has not made in detail yet. In topography survey UAV, ortho-images DSM (Digital Surface Model) data were constructed through imaging ground control point (GCP) surveying ground. case ortho-images, VRS was used...

BACKGROUND The present study was conducted to evaluate the effect of different topical agents utilized for prevention of enamel decalcification around orthodontic brackets bonded to bleached and non-bleached enamel. METHODS Human maxillary premolars (n = 120) were divided into two equal groups. Teeth in group I were left without bleaching while those in group II were bleached with Vivastyle g...

Reaction of ortho-carborane with anhydrous AlCl3 in chloroform results a mixture 9-chloro, 9,12-dichloro, and 8,9,12-trichloro derivatives 9,12-dichloro-ortho-carborane being the main product. Molecular crystal structure was determined by single X-ray diffraction. The 9,12-Cl2-1,2-C2B10H10 appeared to be nearly isostructural 9,12-dibromo-ortho-carborane: packing is built layers which molecules ...

We investigate the relationships between acylation defects and structure alterations due to base substitutions in yeast mitochondrial (mt) tRNA(UUR)(Leu). The studied substitutions are equivalent to the A3243G and T3250C human pathogenetic tRNA mutations. Our data show that both mutations can produce tRNA(UUR)(Leu) acylation defects, although to a different extent. For mutant A14G (equivalent t...

The src family tyrosine kinase p59fyn binds to a signaling motif contained in subunits of the TCR known as the immune-receptor tyrosine-based activation motif (ITAM). This is a specific property of p59fyn because two related src family kinases, p60src and p56lck, do not bind to ITAMs. In this study, we identify the residues of p59fyn that are required for binding to ITAMs. We previously demonst...

N-hydroxysuccinimide (NHS) esters are derivatizing agents that target primary amine groups. However, even a small molar excess of NHS may lead to acylation of hydroxyl-containing amino acids as a side reaction. We report a straightforward method for the selective removal of ester-linked acyl groups after NHS ester-mediated acylation of peptides and proteins. It is based on incubation in a boili...

This study was designed to examine the metabolic fate of exogenous lauric acid in cultured rat hepatocytes, in terms of both lipid metabolism and acylation of proteins. Radiolabeled [14C]-lauric acid at 0.1 mM in the culture medium was rapidly taken up by the cells (94.8 +/- 2.2% of the initial radioactivity was cleared from the medium after a 4 h incubation) but its incorporation into cellular...

RNA molecules depend on structural elements that are critical for cellular function. Chemical methods for probing RNA structure have emerged as a necessary component of characterizing RNA function. As such, understanding the limitations and idiosyncrasies of these methods is essential for their utility. Selective hydroxyl acylation has emerged as a common method for analyzing RNA structure. Est...