DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate stiff double-stranded DNA components and flexible single-stranded DNA component...

Controlled nucleation of nanoscale building blocks by geometrically defined seeds implanted in DNA nanoscaffolds represents a unique strategy to study and understand the dynamic processes of molecular self-assembly. Here we utilize a two-dimensional DNA origami frame with a hollow interior and selectively positioned DNA hybridization seeds to control the self-assembly of DNA tile building block...

Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such and controllability. Recently, DNA nanotechnology, especially origami technology, has been useful the bottom-up fabrication of well-defined nanostructures ranging from tens nanometres to sub-micrometres. In this Primer, we summarize methodologies including desi...

Abstract Moulding the flow of phononic waves in three-dimensional (3D) space plays a critical role controlling sound and thermal properties matter. To this end, 3D crystals (PnCs) have been considered gold standard because their complete bandgap (PnBG) enables omnidirectional inhibition wave propagation. Nevertheless, achieving PnBG high-frequency regime is still challenging, as attaining corre...

Here, we report a simple and rapid characterisation technique combining physical and chemical analysis for DNA origami with conventional TEM.

DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigat...

We consider origami in the context of complex numbers and algebra. In an origami construction, we start with a sheet of paper that we can consider to be infinitely large. The sheet of paper also has two points marked on it: 0 and 1. The sheet represents the complex plane, with the real axis going through the points 0 and 1 and the imaginary axis perpendicular to the real axis, intersecting it a...