Objective: The aim of this study was to investigate the physicochemical and microbiological stability extemporaneous amitriptyline hydrochloride (AMH) topical preparations for treatment neuropathic pain. Materials Methods: AMH tablets were triturated produce fine powders with a mortar pestle. These levigated separately incorporated into four compounding bases: hydrophilic petrolatum USP, anioni...

Some organic compounds form gels in liquids by forming a network of anisotropic fibres. Based on extensive solubility tests of four gelators of similar structures, and on Hansen solubility parameter formalism, we have probed the quantitative effect of a structural variation of the gelator structure on its gel formation ability. Increasing the length of an alkyl group of the gelator obviously re...

BACKGROUND Esterases with excellent merits suitable for commercial use in ester production field are still insufficient. The aim of this research is to advance our understanding by seeking for more unusual esterases and revealing their characterizations for ester synthesis. METHODOLOGY/PRINCIPAL FINDINGS A novel esterase-encoding gene from Rhizomucor miehei (RmEstA) was cloned and expressed i...

Synthetic polymer actuators have attracted increasing attention for their potential applications in artificial muscles, soft robotics and sensors. The majority of previous efforts have focused on smart hydrogels with bilayer structures that can change their shape in response to environmental stimuli, such as temperature, light and certain chemicals. However, the practical application of hydroge...