A pharmaceutical raw material is every active or inactive substance used in the manufacturing process of a pharmaceutical dosage form. According to their function in the medicament, they could be classified into two groups: (i) active ingredients with pharmacological activity; and (ii) excipients which allow the active ingredients dosification and makes suitable the route of administration (de ...

The National Center for Health Statistics collaborated with the National Human Monitoring Program of the U.S. Environmental Protection Agency (EPA) in a four-year study to assess the exposure of the general population to selected pesticides through analysis of blood serum and urine specimens. Specimens were collected on a national probability half-sample of persons 12-74 years of age from 64 lo...

BACKGROUND Pesticide exposure may be positively associated with depression. Few previous studies have considered the episodic nature of depression or examined individual pesticides. OBJECTIVE We evaluated associations between pesticide exposure and depression among male private pesticide applicators in the Agricultural Health Study. METHODS We analyzed data for 10 pesticide classes and 50 s...

In Malaysia, rivers are the main source of public water supplies. This study was conducted from 2002 to 2003 to determine the levels of selected organochlorine and organophosphate pesticides in the Selangor River in Malaysia. Surface water samples have been collected seasonally from nine sites along the river. A liquid-liquid extraction followed by gas chromatography-mass spectrometry technique...

Southern Spain has the largest area of intensive greenhouse agriculture in Europe, and may constitute a special case of occupational and female exposure, because this type of farming requires considerable pesticide use and employs many women. We measured adipose tissue levels of 14 organochlorine pesticides in 458 women living in this area and analyzed the relationship between pesticide level/p...

This study investigated the presence and levels of organochlorine pesticides (OCPs) (hexachlorobenzene (HCB), α‐, β‐, δ‐, and γ‐hexachlorohexane (HCH), dieldrin, dichloro-diphenyltrichloroethane (p,p’-DDT), dichloro-diphenyl-dichloroethylene (p,p’-DDE), dichloro-diphenyldichloroethane (p,p’-DDD) and trans-nonachlor) in Solanum lycopersicum and Capsicum annuum samples commercially sold in Nigeri...

Some organochlorine pesticides and other synthetic chemicals mimic hormones in representatives of each vertebrate class, including mammals, reptiles, amphibians, birds, and fish. These compounds are called endocrine-disrupting chemicals (EDCs). Similarly, hormonelike signaling has also been observed when vertebrates are exposed to plant chemicals called phytoestrogens. Previous research has sho...

Pesticides including organochlorine pesticides (OCPs), organophosphorus pesticides (OPPs), and nitrogen-containing herbicides are types of well-known environmental contaminants. Pesticides are generally categorized based upon their persistence in the environment. Organochlorine pesticides are considered persistent pesticides. These pesticides have long environmental half-lives and tend to bioac...

pesticides are one of the major pollutants in the environment. the residue of pesticides has been reported to be at a critical level in agricultural crops, especially in greenhouse crops. tomato is considered as an important vegetable in iranian food basket and is produced in fields and greenhouses. so, the current study aimed to assess diazinon and oxydemeton-methyl levels in tomatoes sampled ...

Pesticides have been suspected to act as endocrine disruptive compounds (EDCs) through several mechanisms of action, however data are still needed for a number of currently used pesticides. In the present study, 30 environmental pesticides selected from different chemical classes (azole, carbamate, dicarboximide, organochlorine, organophosphorus, oxadiazole, phenylureas, pyrazole, pyrimidine, p...