In this tutorial review, we discuss the utilization of chemical shift information as well as ab initio calculations of nuclear shieldings for protein structure determination. Both the empirical and computational aspects of the chemical shift are reviewed and the role of molecular dynamics and the accuracy of different computational methods are discussed. It is anticipated that incorporating the...

The aim of the paper is to define the role of corporate responsibility in sustainable development of global firms. To be successful, global firms must be on the alert of emerging environmental trends and do their best to improve the corporate performance in line with key stakeholder expectations. In this respect, the management of corporate social responsibility highlights the criticality of th...

Comparative modeling is becoming an increasingly helpful technique in microbial cell factories as the knowledge of the three-dimensional structure of a protein would be an invaluable aid to solve problems on protein production. For this reason, an introduction to comparative modeling is presented, with special emphasis on the basic concepts, opportunities and challenges of protein structure pre...

In this paper a simple, single-level strategic game, namely the Minority Game (MG), will be extended to form a hierarchical organization. The individual MGs will form a group, and individual players within each MG will make decisions which depend on the average behavior of their own and other MGs. Calculations show that under certain conditions the elements of the individual MGs “know” much mor...

In this paper, we present a self-organized computing approach to solving hard combinatorial optimization problems, e.g., the traveling salesman problem (TSP). First of all, we provide an analytical characterization of such an approach, by means of formulating combinatorial optimization problems into autonomous multi-entity systems and thereafter examining the microscopic characteristics of opti...

Until a few decades ago, the police were mainly a reactive bureaucratic organization that moved from one criminal event to the next, according to the degree to which the outside world required its services. Since then the police have abandoned the emphasis on law enforcement with regards to petty crime and public order. More recently the police have developed community policing as an important ...

In origami, form follows the sequential spatial organization of folds. This requires continuous intervention and raises a natural question: Can origami arise through self-organization? We answer this affirmatively by examining the possible physical origin for the Miura-ori leaf-folding patterns that arise naturally in insect wings, leaves, and other laminae-like organelles. In particular, we po...

The firm scientific basis for organized stroke care is relatively short, little more than 10 years. During the past year, existing knowledge has not only been consolidated but also extended in several areas with important implications on clinical practice. Three areas can be identified: (1) organization of prehospital services, (2) hospital treatment, and (3) follow-up care. Progress has been h...

A model for traffic flow in street networks or material flows in supply networks is presented, that takes into account the conservation of cars or materials and other significant features of traffic flows such as jam formation, spillovers, and load-dependent transportation times. Furthermore, conflicts or coordination problems of intersecting or merging flows are considered as well. Making assu...