This study was conducted to assess the in vivo and ex vivo immunomodulatory effect of the ethanol leaves extract of Moringa peregrina in Balb/c mice. For this study, five groups of 5 Balb/c mice were given a single acute subtoxic oral dose of the ethanolic extract at 1.13, 11.30, 23.40 and 113.4 mg/kg and the immunomodulatory effect was assessed on the 6th day following the ingestion. In the (n...

PURPOSE BMS-214662 is a nonsedating benzodiazepine derivative that exhibits broad spectrum cytotoxicity against human solid tumor cell lines and potently inhibits farnesylation of the H-ras and K-ras oncogenic proteins. This report describes the initial Phase I clinical trial of the compound. The main objective of the study was to determine the dose-limiting toxicities and the maximum tolerated...

Computed tomography (CT) has had a massive impact on diagnostic radiology over the past few decades. Serious concerns exist because of increase in effective radiation dose associated with CT scans, which could pose significant health risks. In CT, can be estimated by Monte Carlo simulations. The aim study was to estimate and compare doses for from organ dose-based calculations using tissue weig...

Dose distribution inside the human body due to external photon exposure was measured. Radiation detectors were imaging plate (IP) sheets and thermoluminescent dosimeters (TLD). Each IP sheet was installed between horizontally sliced pieces of a rando-phantom. TLDs were also installed inside/around the position of a target organ of the phantom. The rando-phantom was exposed to a photon beam of C...

Background: The purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. Materials and Methods: Human peripheral blood lymphocytes were irradiated using proton beams (LET: 34.6 keV μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (CB) micronucleus (MN) assay. To determine th...

Introduction Organ-based tube current modulation (OBTCM) is designed for anterior dose reduction in Computed Tomography (CT). The purpose was to assess capability chest CT using three organ systems at different kVp settings. Furthermore, noise, diagnostic image quality and tumour detection assessed. Methods A Lungman phantom scanned with without OBTCM 80–135/140 scanners; Canon Aquillion Prime,...

Introduction Gallium-67 ( 67 Ga) has been used as a radionuclide for imaging a variety of solid tumors since 1969. Since then use of various gallium-based radiotracers has been reported. Recently, 67 Ga-labeled acetylacetate bis(thiosemicarbazones) ( 67 Ga-AATS) complex with significant tumor accumulation and fast blood clearance has been employed. Materials and Methods In this study, the absor...