Cardiorenal syndrome (CRS) describes the inter-relationship and complex pathophysiological processes by which dysfunction of either the heart or the kidneys is related to dysfunction in the other organ system. Historical definitions may have been overly simplistic; newer definitions have tried to capture the complex interactions and feedback processes which exist between the two organs. These d...

Systemic medical conditions may cause central and peripheral nervous system dysfunction. It is important to recognize that the function of all organ systems is to keep the brain alive. If treatment is initiated for systemic organ failure (i.e., medication, transplantation, surgery), these may be associated with other types of neurological disorders. Rather than memorizing lists of neurological ...

Introduction Sepsis remains a major cause of morbidity and mortality in neonates, particularly among preterm infants. (1) Impaired microcirculatory blood flow plays a pivotal role in the development of clinical manifestations and organ dysfunctions in severe sepsis and septic shock. (2)(3)(4) If not corrected, microcirculatory dysfunction can progress to organ dysfunction and subsequently to or...

The current study was conducted to correlate the level of DNA damage with multiorgan dysfunction (MOD) in perinatal asphyxia. Among the 80 cases with MOD, 25% each of the babies had five and four organ system involvement , while 23.8% of babies had involvement of 3 systems and 26.3% had 2 organ system dysfunction. The DNA damage increased with the number of systems involved. The comet tail leng...

INTRODUCTION Cardiovascular surgery with cardiopulmonary bypass (CPB) has improved in past decades, but inflammatory activation in this setting is still unpredictable and is associated with several postoperative complications. Perioperative levels of macrophage migration inhibitory factor (MIF) and other inflammatory mediators could be implicated in adverse outcomes in cardiac surgery. METHOD...

BACKGROUND Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction. METHODS The isometric tension was recorded in isolated segments of the rat mesenteric artery branch, before and after organ culture for 20 h. Vasodilatation was expresse...

Severe sepsis is a systemic inflammatory response to infection resulting in acute organ dysfunction. Vascular perfusion abnormalities are implicated in the pathology of organ failure, but studies of microvascular function in human sepsis are limited. We hypothesized that impaired microvascular responses to reactive hyperemia lead to impaired oxygen delivery relative to the needs of tissue and t...

Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune ...

OBJECTIVE To evaluate the role of complement factor C5 in a model of zymosan-induced multiple organ dysfunction syndrome. DESIGN Experimental animal study. SETTING Central animal laboratory of a university hospital. SUBJECTS Twenty-five C5-deficient B2D10/Old and 25 C5-sufficient B2D10/New mice. INTERVENTIONS On day 0, all mice received an intraperitoneal injection with zymosan suspende...

The giant panda (Ailuropoda melanoleuca) is one of the most endangered species in world. Climate change and susceptibility to disease are two greatest threats this species. We performed a necropsy histopathological examination organs an old investigated pathogenesis associated with death. Necropsy observation revealed some typical age-related lesions, such as cataract, atherosclerosis, renal in...