OBJECTIVE The purpose of this study was to examine the stability of a generic lansoprazole product in a 3 mg/mL sodium bicarbonate suspension under room temperature and refrigerated conditions. METHODS Lansoprazole suspensions (3 mg/mL) were prepared in triplicate using an 8.4% sodium bicarbonate vehicle for each storage condition (room temperature and refrigerated). During 1 month, samples f...

Oxymorphone is a potent opioid analgesic. Oral administration of oxymorphone to rats at doses >or= 20 mg/kg and mice at 500 mg/kg produced an increase in micronucleated polychromatic erythrocytes (MPCEs). Oxymorphone does not produce chromosome aberrations in vitro, suggesting that the increased MPCEs in vivo may involve indirect mechanisms. Opioids are known to affect thermoregulatory mechanis...

BACKGROUND Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics. OBJECTIVE The aim of this pilot study is to evaluate the feasibility of using a Chinese proprietary medicine, Yin Qiao San (YQS), for fever relief. METHODS A single centre, open label, prospective clinical trial exp...

This study investigated and compared the effects of active and passive warm-up on oral temperature and cardiovascular parameters of forty (20 males and 20 females) apparently healthy undergraduates. Subjects whose mean age was 22.6±1.37years acted as their own controls. During active warm-up (AWU) subjects rode on an unloaded bicycle ergometer for 15 minutes while they received infra-red radiat...

Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less efficient in crossing the blood brain barrier for brain targeting through oral delivery. To overcome this problem the various system such as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermoreversible mucoadhesive gels etc have been studied for n...

We previously reported the development and clinical efficacy of a 2% aspirin oral ointment and 2% ethenzamide oral ointment as hospital preparations for painful lesions of the oral mucosa. This study investigated methods of preparing a more stable oral ointment with a more effective analgesic action, using diflunisal, another salicylic acid derivative, with an analgesic effect stronger than tha...

UNLABELLED Theme: Transition of care. INTRODUCTION Oral feeding is one of the hardest steps for premature infants after respiratory independence and is a challenge for nurses in neonatology. OBJECTIVES To know the characteristics of preterm infants, essential for oral feeding; to know the nurses' opinion on nursing interventions, that promote the transition of gavage feeding for oral feedin...