BACKGROUND Hypertonic saline/dextran (HSD) fluid resuscitation has been demonstrated to be effective in alleviating the adverse effects of hemorrhagic hypotension. The optimal dose of HSD has not been defined. METHODS he comparative effectiveness of various dosages of HSD for the treatment of severe hemorrhage was investigated in conscious swine bled 46 mL/kg over 15 minutes, a lethal procedu...

A dose/response study has been carried out in seven patients with endoscopically proven duodenal ulcers in symptomatic remission, measuring intragastric pH and gastric acid output overnight after a bedtime dose of ranitidine (75 mg, 150 mg, and 300 mg); and the results have been compared with placebo and with bedtime cimetidine 400 mg. The currently recommended ranitidine maintenance dose (150 ...

The antileukemic activity (medium effective dose, MED) of a set of 37 carboquinones was modeled using a combination of the electrotopological state (E-state) and molecular connectivity indices with multiple linear regression. A four-variable model gave good statistics: r2 = 0.90, s = 0.21. Using the leave-one-out method, the cross-validation statistics indicate a model useful for prediction: r2...

Skin injury is a deterministic effect of radiation. Once a threshold dose has been exceeded, the severity of the radiation effect at any point on the skin increases with increasing dose. Peak skin dose is defined as the highest dose delivered to any portion of the patient's skin. Reducing peak skin dose can reduce the likelihood and type of skin injury. Unfortunately, peak skin dose is difficul...

although the indian population is largely vegetarian, not much attention has been given to the cultivation of vegetables, as compared to other crops like cereals, pulses and oil seeds. therefore, the present study was conducted on two leafy vegetables, spinach (spanacia oleracea l.) and methi (trigonella foenum graecum l.) commonly grown in aligarh, as the two popular vegetables of indian diet....

We compare two multiobjective evolutionary algorithms, with deterministic gradient based optimization methods for the dose optimization problem in high-dose rate (HDR) brachytherapy. The optimization considers up to 300 parameters. The objectives are expressed in terms of statistical parameters, from dose distributions. These parameters are approximated from dose values from a small number of p...

Introduction: Tranexamic acid (TXA) is routinely used during cardiac surgical procedures involving cardiopulmonary bypass (CPB) in order to reduce blood loss [1]. Although the optimum dose of TXA has been a subject of debate, a dosing regimen also sometimes referred to as the BART dose remains a popular choice for high-risk cardiac surgery [2]. The pharmacokinetics of TXA during the perioperati...

The effectiveness of the new schistosomicide praziquantel was assessed in African schoolchildren infected with Schistosoma haematobium. They were stratified according to the severity of their infection and were then randomly allocated to treatment with two single-dose regimens (30 and 40 mg/kg) and a split regimen of two doses of 20 mg/kg given four hours apart. All three regimens were highly e...

Introduction In order to treat uveal Melanoma , first, radioactive seeds are laid on a silicone- made substance which is called Silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. The dose gradient within the tumor and healthy tissues can be varied due to changing the Silastic thickness between scler...

Abstract Research has been carried out on seaweed-based irradiated functional food ingredients (carrageenan and alginate). This research aimed to determine analyze the effect of irradiation Physico-chemical microbiological quality ingredients. Sample preparation was by preparing carrageenan alginate flour, then packaged with gamma rays at doses 3, 5, 7 kGy (0 as control). Samples were stored ro...