Critical issues in determining therapeutic strategies for patients with myelodysplastic syndromes (MDSs), who usually die of bone marrow failure with or without conversion to acute myeloid leukemia (AML), include host factors in these mainly older patients, disease heterogeneity, lack of pathogenetic understanding, and a dearth of effective treatments. Even the issue of whether these clonal dis...

Biogeography studies that correlate the observed distribution of organisms to environmental variables are typically based on local conditions. However, in cases with substantial translocation, like planktonic organisms carried by ocean currents, selection may happen upstream and local environmental factors may not be representative of those that shaped the local population. Here we use an indiv...

Strain distribution of Al 1100 was numerically investigated during cyclic expansion extrusion (CEE) process using finite element method (FEM). Die angle, corner fillet radius and die chamber diameter were considered as die parameters and friction factor and number of passes as process parameters. The effects of these parameters were investigated on the effective strain and strain homogeneity in...

The paper revises and improves on a Dual Type Method DTM devel oped by A Pr ekopa in two ways The rst improvement allows us in each iteration to perform the largest step toward the optimum The second inprovement consists of exploting the structure of the working basis which has to be inverted in each iteration of the DTM and updating its inverse in product form as it is usual in case of the sta...

In embedded systems, cost, power consumption, and die size requirements push the designer to use small and simple cache memories. Such caches can provide low performance because of limited memory capacity and inflexible placement policy. A way to increase the performance is to adapt the program layout to the cache structure. This strategy needs the solution of a N-P complete problem and a very ...

The quality of Shea butter is highly affected by processing factors. Hence, the aim of this work was to evaluate the effects of conditioning duration (CD), moisture content (MC), and die temperature (DT) of screw expeller on Shea butter quality. A combination of 33 full factorial design and response surface methodology was used for this investigation. Response variables were refractive index, a...

The Network-on-Chip (NoC) is an enabling technology to integrate large numbers of embedded cores on a single die. The existing methods of implementing a NoC with planar metal interconnects are deficient due to high latency and significant power consumption arising out of multi-hop links used in data exchange. To address these problems, we propose design of a hierarchical small-world wireless No...

Electronic appendices are refereed with the text; however, no attempt is made to impose a uniform editorial style on the electronic appendices.

This paper studied the deformation mechanisms of sheet metals stamped by rigid punches and deformable dies. Emphasis was placed on the development of elastic plastic zones in the sheet workpieces, on the functions of the die parameters and on their correlations with spring-back. It was found that the reduction of spring-back was due mainly to the interface interaction offered by the dies. The p...