The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

BACKGROUND Medication adherence is essential to achieve successful methadone maintenance treatment (MMT). However, treatment adherence among MMT patients in the mountainous setting in Vietnam has not been yet investigated. This study aimed to explore the medication adherence and associated factors in MMT patients in Tuyen Quang, a mountainous province. METHODS A cross-sectional survey was con...

Objective: Therapeutic drug monitoring (TDM) is the measurement of serum concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used evaluate antihypertensive response. However, approximately 50 % hypertensive patients treated by lifestyle changes drugs fail achieve control. Serum concentration could be useful select optimal in adjus...

‎in this paper‎, ‎we consider the optimal asset control of a financial company which can control its liquid reserves by paying dividends and by issuing new equity‎. ‎we assume that the liquid surplus of the company in the absence of control is modeled by the diffusion model‎. ‎it is a hot topic to maximize the expected present value of dividends payout minus equity issuance until the time of ba...

abstract the use of water sources has increased due to extend of agricultural activity for answering food needs of increasing population. while because of exploitation and consumption of water, the use of this restricted resource is not appropriate. consequently in many districts of country the head level of ground water aquifers have been fallen and water level is negative. so, application of ...