Glucocorticoids (GCs) have been an invaluable tool in the treatment of patients with rheumatoid arthritis (RA) for decades, with a focus mainly on symptom management. In addition, several studies in the last 15 years have shown that GCs are also disease-modifying in patients with RA - which implies that they inhibit radiographic progression. These effects seem to be especially important in the ...

The antiarrhythmic efficacy of propranolol was evaluated in 32 patients with chronic high frequency ventricular arrhythmias in a placebo-controlled protocol. After a placebo control period, propranolol was begun and the dosage increased sequentially until arrhythmia suppression was achieved, side effects appeared, or a maximum dosage of 960 mg/day was reached. Computerized analysis of ambulator...

ABTRACT Because of the narrow therapeutic range and large inter-patient variability in digoxin’s pharmacokinetics and pharmacodynamics, an appropriate dosage regimen for individuals is needed. However, monitoring and adjusting the optimal individualized dosage regimen requires a knowledge and familiarity of pharmacokinetic equations. The objective of this study was to develop a computer-based p...

Coagulation-flocculation is the most important parts of water treatment process. Traditionally, optimum pre coagulant dosage is determined by used jar tests in laboratory. However; jar tests are time-consuming, expensive, and less adaptive to changes in raw water quality in real time. Soft computing can be used to overcome these limitations. In this paper, multi-objective evolutionary Pareto op...

OBJECTIVE D-Fraction, a polysaccharide extracted from maitake mushrooms (Grifola frondosa), has been reported to exhibit an antitumor effect through activation of immunocompetent cells, including macrophages and T cells, with modulation of the balance between T-helper 1 and 2 cells. We examined whether D-Fraction could decrease the effective dosage of the chemotherapeutic agent, mitomycin-C (MM...

BACKGROUND AND OBJECTIVES The prescription and delivery of renal replacement therapy for acute kidney injury is subject to a wide variation and is conditioned by a multiplicity of factors. A variety of renal replacement therapy modalities are now available to treat acute kidney injury; however, there are no standards for the dosage, choice of modality, and intensity and duration of these therap...

adsorption of cations al, zn, fe, cr and pb from aqueous solution of hydrogen peroxide using ir-120 cation-exchange resin was studied. the removal percentage of the cations was examined by varying experimental conditions (such as ph of the hydrogen peroxide solution, temperature, contact time and dosage of adsorbent) in a stirred-batch system. under the optimal conditions (ph=1, t=25oc, contact...

heavily polluted wastewater from sanitary landfill presents the leachate characteristics that need special treatment and disposal. concentration of chemical oxygen demand (cod), ammonia nitrogen (nh3-n), heavy metal and other pollutant content are often larger than standard requirement after applying biological/physico-chemical treatment.thus, the combination of coagulationflocculation and chem...

in recent years, the nanoscale zero-valent iron (nzvi) particles have been used successfully for the degradation of hydrocarboncompounds and remediation of other pollutants. nevertheless, as far as we know, there is no specific study on the improvement of thegeotechnical properties of contaminated soils with hydrocarbon compounds by nzvi. this study used nzvi particles to remove gasoil in a cla...

Oral sodium phosphate formulations indicated for hypophosphatemia are commercially available worldwide. In Japan, however, many medical institutes have used hospital dispensary or foreign over-the-counter formulations because no such medication with an indication covered by the health insurance system is domestically available. To address this problem, we initiated the development of Phosribbon...