According to the industrial requirement for optical imaging, particularly in microscopic imaging, resolution improvement is one of the most important issues. In digital microscopic imaging, resolution of an optical system is limited by both optical parameters such as light wavelength and the objective lens numerical aperture and by spatial sampling such as pixel size of charge-coupled device ca...

Diffuse optical tomography (DOT) has emerged in the last decade as a new and exciting tool for functional medical imaging with applications in a range of areas including breast cancer detection and diagnosis. DOT employs observations of near infrared (NIR) light that has propagated through tissue to reconstruct the spatial distribution of various chromophores present in the region of interest. ...

The Geant4 Application for Emission Tomography (GATE) is an advanced open-source software dedicated to Monte-Carlo (MC) simulations in medical imaging involving photon transportation (Positron emission tomography, single photon emission computed tomography, computed tomography) and in particle therapy. In this work, we extend the GATE to support simulations of optical imaging, such as biolumine...

Recent research demonstrates the advantage of designing electro-optical imaging systems by jointly optimizing the optical and digital subsystems. The optical systems designed using this joint approach intentionally introduce large and often space-varying optical aberrations that produce blurry optical images. Digital sharpening restores reduced contrast due to these intentional optical aberrati...

We have developed novel optical micro-electro-mechanical systems, (MEMS) and nano-electro-mechanical, (NEMS) optical components for applications including imaging, switching, and optical integrated circuits. This paper provides an overview of current optical MEMS/NEMS research projects in our integrated photonics laboratory at UCLA. Three optical MEMS/NEMS devices: a large, 1 mm diameter, scann...

Photoacoustic (PA) or optoacoustic imaging is a relatively new imaging modality based on the detection of light-excited ultrasound waves, has emerged as one of the most exciting research areas in biomedical imaging over the past decade [1-4]. In PA imaging, nanosecond pulsed (or modulated) electromagnetic radiation is delivered into tissues to excite ultrasound waves via photon absorption and t...

Non-invasive optical imaging of brain function has been promoted in a number of fields in which functional magnetic resonance imaging (fMRI) is limited due to constraints induced by the scanning environment. Beyond physiological and psychological research, bedside monitoring and neurorehabilitation may be relevant clinical applications that are yet little explored. A major obstacle to advocate ...

In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times...

We present a method for depth discrimination in parallel-plate, transmission mode, diffuse optical imaging. The method is based on scanning a set of detector pairs, where the two detectors in each pair are separated by a distance δDi along direction δ D i within the x-y scanning plane. A given optical inhomogeneity appears shifted by αi δ D i (with 0≤ αi ≤1) in the images collected with the two...

Teknillinen korkeakoulu Informaatio-ja luonnontieteiden tiedekunta Lääketieteellisen tekniikan ja laskennallisen tieteen laitos Article dissertation (summary + original articles) Monograph Faculty Department Field of research Opponent(s) Supervisor Instructor Abstract Keywords diffuse optical imaging, monte carlo, biomedical optics Accurate modelling of tissue properties in diffuse optical imag...