The analysis of spectroscopic optical coherence tomography (SOCT) signals suffers the trade-off between time resolution and frequency resolution. Various joint time-frequency distributions (TFDs) can optimize this trade-off. Synthesized signals were generated and experimentally acquired data were obtained to compare and validate several different TFDs under different SOCT imaging schemes. Speci...

In a numerical study, we investigate a diffuse-photon computed tomography of a turbid medium. Using a perturbation approach, we relate through a matrix K a bulk heterogeneous distribution of the optical absorption coefficient &mgr;(a) that characterizes the heterogeneity in an otherwise homogeneous turbid medium to the diffuse photon flux that emerges from its surface. By studying the condition...

diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. thus, the need for precise segmentation of corneal layer boundaries is inevitable. obviously, manual segmentation is time‑consuming and imprecise. in this paper, the gaussian mixture model (gmm) is used for automatic segmentation of three clinically important corneal boundaries on opt...

purpose : to report the evaluation of the treatment response in choroidal hemangioma with application of enhanced depth imaging optical coherence tomography (edi-oct) technique case report : a 73-year-old woman with a circumscribed choroidal hemangioma in the posterior pole of her left eye underwent photodynamic therapy and intravitreal injection of bevacizumab. edi-oct obtained from the affect...

Doppler optical coherence tomography (DOCT) is a valuable tool for depth-resolved flow measurements in tissue. However, DOCT is insensitive to flow in the direction normal to the imaging beam and requires knowledge of the phase of the demodulated signal. We present an alternative method of extracting flow information, using speckle of conventional amplitude optical coherence tomography images. ...

Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. The current state of the art of NIR fluorescence-enhanced optical tomography is reviewed in the context of the principle of fluorescence, the different measurement schemes employed, and the mathematical t...

Fiber imaging bundles have been investigated for use in endoscopic optical coherence tomography (OCT) systems, to obviate the requirement for scanning components within the endoscope probe section. Images have been acquired using several optical configurations, two of which are common path in design. Configurations have been selected as having potential for miniaturization and inclusion in endo...

We report the use of a tunable differential interferometer for optical tomography. This interferometer has several advantages over other methods for phase measurements in optical tomography, including good stability, variable sensitivity, and the elimination of fringe ambiguity. Quantitative images of the gas concentrations in subsonic jets of methane and oxygen issuing into air are presented, ...

Optical coherence tomography images of human enamel were simulated and compared to measured images. A Monte Carlo code was implemented, which considered the microstructure of enamel. The prisms, the main scattering structures of the enamel, were described by oscillating cylinders whose scattering functions were obtained by solutions of Maxwell's equations. The essential features of the measured...

Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection technique is proposed to detect pulsed US modulated light using a multipixel detector. The frequency components of the pass band match those of the US pulse train and provide efficient detection....