PURPOSE Acetazolamide was previously shown to increase optic disc partial pressure of oxygen (PO(2)). The study was conducted to evaluate optic disc PO(2) variations during normoxia, hyperoxia (100% O(2)), and carbogen breathing (95% O(2), 5% CO(2)), before and after intravenous administration of acetazolamide. METHODS PO(2) measurements were obtained at intervascular areas of the optic disc ...

OBJECTIVE To determine the prevalence of tilted and torted optic discs and associated risk factors among Chinese adults in Singapore. METHODS As part of a population-based survey, optic disc stereophotographs of both eyes were obtained, and left eyes were analyzed using imaging software. A tilted optic disc was defined as an index of tilt (ratio of minimum to maximum optic disc diameter) less...

Optic disc (OD) and fovea locations are two important anatomical landmarks in automated analysis of retinal disease in color fundus photographs. This paper presents a new, fast, fully automatic optic disc and fovea localization algorithm developed for diabetic retinopathy (DR) screening. The optic disc localization methodology comprises of two steps. First, the OD location is identified using t...

AIMS To find out whether the size of the blind spot area, determined by static perimetry, depends on the surface topography of the optic disc and its surrounding area. METHODS Ten eyes were examined; all had a parapapillary atrophy adjacent to the temporal side of the disc. Microperimetry was performed under direct fundus control using a Rodenstock scanning laser ophthalmoscope. The horizonta...

PURPOSE To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. DESIGN Cross-sectional, observational study. SUBJECTS Twenty-eight normal, 30 POAG, and 31 NTG subjects. METHODS One eye from each subject was scan...

PURPOSE To examine the roles of genetic and environmental factors in the optic disc in a classic twin study. METHODS Five hundred six pairs of twins were recruited to participate from the Twins U.K. Adult Twin Registry at St. Thomas' Hospital, London. Photographs of the optic disc were obtained, and the covariance of optic disc, cup, and rim areas within monozygotic (MZ) and dizygotic (DZ) pa...

The purpose of this study was to evaluate the relationship between central corneal thickness (CCT) and optic disc morphology in normal tension glaucoma (NTG). Patients with NTG underwent eye examination, optic disc imaging with Heildelberg Retina Tomograph II (HRT II) and ultrasound corneal pachymetry. The morphological parameters of the optic discs were used to classify the eyes into four grou...

P eriventricular leucomalacia is an end stage lesion that results from hypoxic-ischaemic injury to the white matter of the developing brain. This condition occurs in 32% of premature infants and is believed to develop between the 24th and 34th weeks of gestation. Periventricular leucomalacia most commonly involves the optic radiations adjacent to the trigone of the lateral ventricle, and the an...

This study was to analyse the degeneration of the Retinal Nerve Fiber Layer (RNFL) and optic disc and the relationship between optic nerve damage and the severity of cognitive impairment in patients with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). The RNFL thickness and optic disc variables were assessed by optical coherence tomography in patients with MCI and AD and control s...

PURPOSE In a recent study, we found the presence of serum autoantibody against neuron-specific enolase (NSE) in glaucoma patients. The purpose of the present paper is to investigate further the clinical significance of the presence of the serum antibody against NSE in glaucoma patients. METHODS Serum autoantibody against NSE was examined by Western blot analysis in 143 patients with glaucoma ...