نتایج جستجو برای: opn gene

تعداد نتایج: 1142210  

Journal: :Diabetes 2009
Adeline Bertola Vanessa Deveaux Stéphanie Bonnafous Déborah Rousseau Rodolphe Anty Abdelilah Wakkach Moncef Dahman Joan Tordjman Karine Clément Siobhán E. McQuaid Keith N. Frayn Pierre-Michel Huet Jean Gugenheim Sophie Lotersztajn Yannick Le Marchand-Brustel Albert Tran Philippe Gual

OBJECTIVE Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications in dietary murine models. We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis. RESEARCH DESIGN AND METHODS OPN and CD44 expressions were studied in 52 morbidly obese patients an...

Journal: :FASEB bioAdvances 2023

Abnormal myelination underlies the pathology of white matter diseases such as preterm injury and multiple sclerosis. Osteopontin (OPN) has been suggested to play a role in myelination. Murine OPN mRNA is translated into secreted isoform (sOPN) or an intracellular (iOPN). Whether there isoform-specific involvement unknown. Here we generated mouse models that either lacked both isoforms all cells...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Mohamed K El-Tanani

Osteopontin (opn) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. Opn has pivotal role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Extensive research has demonstrated the pivotal role of opn in regulation of cellular signaling, which controls neoplastic and malignant transformatio...

Journal: :Journal of immunology 2005
Brian Abel Stefan Freigang Martin F Bachmann Ursula Boschert Manfred Kopf

Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN-/-) mice were analyzed after infection with influenza virus and vaccinia virus. Surprisingly, we found that viral clear...

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005
Robert Meller Susan L Stevens Manabu Minami Jennifer A Cameron Sonya King Holly Rosenzweig Kristian Doyle Nikola S Lessov Roger P Simon Mary P Stenzel-Poore

Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic functions, including inflammation, cell migration, and antiapoptotic processes. Here we investigate the neuroprotective potential of OPN to reduce cell death using both in vitro and in vivo models of ischemia. We show that incubation of cortical neuron cultures with OPN protects against cell death from oxy...

Journal: :The Journal of Experimental Medicine 2008
Ryoichi Mori Tanya J. Shaw Paul Martin

Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis. In a series of in vitro and in vivo studies, we analyze the effects of blocking OPN expression at the wound, and determine which inflammatory cells, and which paracrine factors from t...

Journal: :Stroke 2011
Wanqiu Chen Qingyi Ma Hidenori Suzuki Richard Hartman Jiping Tang John H Zhang

BACKGROUND AND PURPOSE Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult experimental models; therefore, we hypothesized that OPN would provide neuroprotection and improve long-term neurological function in the immature brain after hypoxic-ischemic (HI) injury. METHODS HI was induced by unilateral ligation of the right carotid artery followed by hypoxia (8% O(2) for 2 h...

Journal: :Investigative ophthalmology & visual science 2011
Mingliang Chu Peizeng Yang Ranran Hu Shengping Hou Fuzhen Li Yuanyuan Chen Aize Kijlstra

PURPOSE Osteopontin (OPN) is a proinflammatory cytokine involved in chronic inflammatory diseases. This study aimed to analyze the role of OPN in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. METHODS Serum levels of OPN in VKH patients and healthy controls were assayed by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMCs) or CD4+ T cells were cultu...

2018
Xuejiao Li Zhongxiu Jiang Xiangmin Li Xiaoye Zhang

Osteopontin (OPN) is a promoter for tumor progression. It has been reported to promote non-small cell lung cancer (NSCLC) progression via the activation of nuclear factor-κB (NF-κB) signaling. As the increased acetylation of NF-κB p65 is linked to NF-κB activation, the regulation of NF-κB p65 acetylation could be a potential treatment target for OPN-induced NSCLC progression. Sirtuin 1 (SIRT1) ...

2017
Anna Wendt Inês G Mollet Anki Knutsson Victor S Bolmgren Anna Hultgårdh-Nilsson Maria F Gomez Lena Eliasson

Type 2 diabetic patients suffer from insulin resistance and reduced insulin secretion. Osteopontin (OPN), a versatile protein expressed in several tissues throughout the body including the islets of Langerhans, has previously been implicated in the development of insulin resistance. Here we have investigated the role of OPN in insulin secretion using an OPN knock out mouse model (OPN-/-). Ultra...

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