نتایج جستجو برای: opioid substitution therapies

تعداد نتایج: 182726  

Journal: :British journal of pharmacology 2014
Amynah A Pradhan Monique L Smith Jekaterina Zyuzin Andrew Charles

BACKGROUND AND PURPOSE Migraine is an extraordinarily common brain disorder for which treatment options continue to be limited. Agonists that activate the δ-opioid receptor may be promising for the treatment of migraine as they are highly effective for the treatment of chronic rather than acute pain, do not induce hyperalgesia, have low abuse potential and have anxiolytic and antidepressant pro...

Journal: :Journal of managed care pharmacy : JMCP 2010
Lance Nicholls Lisa Bragaw Charles Ruetsch

BACKGROUND In response to the growing incidence of opioid dependence, guidelines have been created, and new treatments are being developed to assist physicians in treating dependence and withdrawal of opioids. OBJECTIVE To review treatment modalities and guidelines utilized in opioid dependence. SUMMARY Guidelines for the treatment of opioid dependence have been developed by organizations s...

Journal: :Substance abuse : research and treatment 2016
Leen Naji Brittany B Dennis Monica Bawor Carolyn Plater Guillaume Pare Andrew Worster Michael Varenbut Jeff Daiter David C Marsh Dipika Desai Lehana Thabane Zainab Samaan

INTRODUCTION Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identify predictors of the length of time a patient receiving MMT for opioid use disorder remains abstinent (relapse-free). METHODS Data were collected from 250 MMT patients enrolled in addiction treatment ...

Journal: :Journal of clinical psychopharmacology 2006
Nicholas Lintzeris Timothy B Mitchell Alyson Bond Liam Nestor John Strang

Benzodiazepine use by patients in methadone and buprenorphine substitution treatment is common, despite safety concerns regarding these drug interactions. The relative safety of diazepam use by methadone- or buprenorphine-treated patients has not been systematically examined. This study aimed to examine the effect of single diazepam doses, within normal therapeutic range (doses: 0, 10, and 20 m...

Journal: :British journal of pharmacology 2011
L Fattore Ms Spano V Melis P Fadda W Fratta

BACKGROUND AND PURPOSE Opioids and cannabinoids interact in drug addiction and relapse. We investigated the effect of the opioid receptor antagonist naloxone and/or the cannabinoid CB(1) receptor antagonist rimonabant on cannabinoid-induced reinstatement of heroin seeking and on cannabinoid substitution in heroin-abstinent rats. EXPERIMENTAL APPROACH Rats were trained to self-administer heroin ...

2010

Opioids have been known to have analgesic properties for thousands of years. The chronic use of opioids for the treatment of chronic noncancer pain has only lately seen increased medical practice [1] owing to a relative lack of efficacy data, until recently, from well-controlled studies. The efficacy of morphine, oxycodone and oxymorphone in extended-release dosage forms has been demonstrated i...

Journal: :Neuron 2011
Shao-Qiu He Zhen-Ning Zhang Ji-Song Guan Hong-Rui Liu Bo Zhao Hai-Bo Wang Qian Li Hong Yang Jie Luo Zi-Yan Li Qiong Wang Ying-Jin Lu Lan Bao Xu Zhang

δ-opioid receptors (DORs) form heteromers with μ-opioid receptors (MORs) and negatively regulate MOR-mediated spinal analgesia. However, the underlying mechanism remains largely unclear. The present study shows that the activity of MORs can be enhanced by preventing MORs from DOR-mediated codegradation. Treatment with DOR-specific agonists led to endocytosis of both DORs and MORs. These recepto...

Journal: :Molecular pharmacology 2000
J Guo Y Wu W Zhang J Zhao L A Devi G Pei L Ma

Agonist-induced receptor phosphorylation is an initial step in opioid receptor desensitization, a molecular mechanism of opioid tolerance and dependence. Our previous research suggested that agonist-induced delta-opioid receptor (DOR) phosphorylation occurs at the receptor carboxyl terminal domain. The current study was carried out to identify the site of DOR phosphorylation during agonist stim...

Journal: :Nuclear medicine and biology 2008
Géraldine Poisnel Farhana Oueslati Martine Dhilly Jérôme Delamare Cécile Perrio Danièle Debruyne Louisa Barré

INTRODUCTION Radiopharmaceuticals that can bind selectively the kappa-opioid receptor may present opportunities for staging clinical brain disorders and evaluating the efficiency of new therapies related to stroke, neurodegenerative diseases or opiate addiction. The N-methylated derivative of JDTic (named MeJDTic), which has been recently described as a potent and selective antagonist of kappa-...

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