We show that the initial value problem associated to the dispersive generalized Benjamin-Ono-Zakharov-Kuznetsov equation ut −D α xux + uxyy = uux, (t, x, y) ∈ R , 1 ≤ α ≤ 2, is locally well-posed in the spaces Es, s > 2 α − 3 4 , endowed with the norm ‖f‖Es = ‖〈|ξ| α + μ〉f̂‖L2(R2). As a consequence, we get the global wellposedness in the energy space E1/2 as soon as α > 8 5 . The proof is based ...

Endotoxin causes acute lung injury resembling acute respiratory distress syndrome. Elastase, as well as reactive oxygen species released from activated neutrophils, are thought to play pivotal roles in the pathogenesis of this lung injury. This study investigated whether ONO-5046, a specific elastase inhibitor, can attenuate acute lung injury induced by endotoxin in rabbits. Thirty-two male ane...

BACKGROUND ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. METHODS A randomised, double-blind, placebo-controlled study was conducted at...

We prove that the Benjamin-Ono equation is globally well-posed in Hs(T) for s ≥ 0. Moreover we show that the associated flow-map is Lipschitz on every bounded set of Hs 0 (T), s ≥ 0, and even real-analytic in this space for small times. This result is sharp in the sense that the flow-map (if it can be defined and coincides with the standard flow-map on H∞ 0 (T)) cannot be of class C , α > 0, fr...