The main aim of the present investigation was to develop in situ gelling mucoadhesive liquid suppositories of ondansetron by using mucoadhesive polymers such as sodium alginate, methyl cellulose and polyvinylpyrrolidone. Polyethylene glycol was used to modify gelation temperature. Mucoadhesive liquid suppositories of ondansetron were prepared by adding mucoadhesive polymers (0.8% w/w) to the fo...

We have studied 746 males and females undergoing general anaesthesia for any type of surgical procedure in a double-blind, controlled, randomized study. After experiencing at least one nausea and/or one emetic episode in the 6 h after recovery from anaesthesia, patients received either ondansetron 4 mg i.v. or metoclopramide 10 mg i.v. Patients were observed for postoperative nausea and vomitin...

Introduction: Postoperative nausea & vomiting (PONV) are common distressing complications of anaesthesia. Pain ,nausea frequently listed by the patient as their most important postoperative concerns. PONV results in increased patientÂ’s discomfort and dissatisfaction. Despite continuing advances anaesthetic surgical technique, both incidence severity remain relatively unchanged. Material Me...

PURPOSE OF REVIEW Acute gastroenteritis (AGE) is a common and impactful disease, typically managed with supportive care. There is considerable interest in the role of adjunctive therapies, particularly ondansetron and probiotics in improving AGE outcomes. The purpose of this review is to present the latest evidence regarding the use of these agents in children with AGE in developed countries. ...

OBJECTIVE To compare the clinical efficacy of acupressure with treatment induced by ondansetron and metoclopramide on reduction of the severity of postoperative nausea and vomiting (PONV) after strabismus surgery. METHODS There were 200 patients with ASA classes I-II, ages 10 to 60 years old, who underwent strabismus surgery that were included in this randomized, prospective, double-blind, pl...

BACKGROUND AND OBJECTIVES Although being considered one of the most effective drugs to control postoperative nausea and vomiting (PONV), ondansetron is unfeasible for routine use due to its high cost. This study aimed at comparing the efficacy of droperidol, metoclopramide, and dexametasone as compared to ondansetron in preventing PONV after gynecological laparoscopies. METHODS Participated i...

Background: Ondansetron, a 5-hydroxytryptamine (5-HT) receptor antagonist, is generally regarded as a safe and well tolerated antiemetic. Meanwhile, some reports mentioned that it is a probable cause of single generalized seizures after intravenous administration. Our report may be the first to indicate repeated generalized seizures after intramuscular therapeutic dose of ondansetron. Methods a...

Postoperative nausea, a common complication in patients receiving general anesthesia, was studied in this randomized investigation to compare the efficacy of 70% inhaled isopropyl alcohol and intravenous ondansetron. For the study, 100 healthy women, ASA physical status I or II, scheduled for outpatient gynecologic laparoscopic procedures randomly received 4 mg of intravenous ondansetron or iso...

UNLABELLED To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups. Group 1 who received up to 2 mL pretreatment 50 mg tramadol in the saline, group 2 cases who received up to 2 mL pretreatment 4 mg ondansetron in saline, and group 3 who received up to 2 mL solution saline. A 20 gauge ca...

We have compared the effects of ondansetron and perphenazine on vomiting after tonsillectomy in 216 healthy children, aged 2-12 yr. The study was randomized, stratified, blocked and double blind. Anaesthesia was induced with propofol i.v. or by inhalation of halothane and nitrous oxide. Ondansetron 150 micrograms kg-1 or perphenazine 70 micrograms kg-1 was administered i.v. after induction of a...