The combination of Dacarbazine (DTIC) with alphainterferon has consistently shown a 30% remission rate in patients with disseminated malignant melanoma (Thomson et al., 1987; Guillou et al., 1989; Mulder et al., 1990). Although some of these remissions, in particular the complete remissions are prolonged, overall results are not satisfactory. Recently, a synergistic effect has been described be...