نتایج جستجو برای: oligodendrocyte precursor cells

تعداد نتایج: 1430626  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Lindsay M De Biase Shin H Kang Emily G Baxi Masahiro Fukaya Michele L Pucak Masayoshi Mishina Peter A Calabresi Dwight E Bergles

Oligodendrocyte precursor cells (OPCs) express NMDA receptors (NMDARs) and form synapses with glutamatergic neurons throughout the CNS. Although glutamate influences the proliferation and maturation of these progenitors in vitro, the role of NMDAR signaling in oligodendrogenesis and myelination in vivo is not known. Here, we investigated the consequences of genetically deleting the obligatory N...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
S Robinson M Tani R M Strieter R M Ransohoff R H Miller

Chemokines, (chemotactic cytokines) are a family of regulatory molecules involved in modulating inflammatory responses. Here we demonstrate that the chemokine growth-regulated oncogene-alpha (GRO-alpha) is a potent promoter of oligodendrocyte precursor proliferation. The proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth fac...

Journal: :Development 2010
Holger Budde Sebastian Schmitt Dirk Fitzner Lennart Opitz Gabriela Salinas-Riester Mikael Simons

The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play an important role in this process by regulating crucial developmental genes. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocyt...

Journal: :Science 2014
Erin M Gibson David Purger Christopher W Mount Andrea K Goldstein Grant L Lin Lauren S Wood Ingrid Inema Sarah E Miller Gregor Bieri J Bradley Zuchero Ben A Barres Pamelyn J Woo Hannes Vogel Michelle Monje

Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs). Electrically active neurons may influence OPC function and selectively instruct myelination of an active neural circuit. In this work, we use optogenetic stimulation of the premotor cortex in awake, behaving mice to demonstrate that neuronal acti...

2016
Ana I. Amaral Mussie G. Hadera Joana M. Tavares Mark R. N. Kotter Ursula Sonnewald

Although oligodendrocytes constitute a significant proportion of cells in the central nervous system (CNS), little is known about their intermediary metabolism. We have, therefore, characterized metabolic functions of primary oligodendrocyte precursor cell cultures at late stages of differentiation using isotope-labelled metabolites. We report that differentiated oligodendrocyte lineage cells a...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1991
B C Warf J Fok-Seang R H Miller

The neuroepithelial cells of the mammalian neural tube are thought to give rise to all classes of differentiated neurons and macroglial cells in the adult CNS. In most cases, the regulation and timing of commitment of neuroepithelial cells to specific differentiative pathways are unknown. It has been proposed that in developing spinal cord, the macroglial cells--astrocytes and oligodendrocytes-...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید