Electrospinning of polymer-free nanofibers (NF) was successfully performed from inclusion complexes (ICs) of modified cyclodextrins [hydroxypropyl-bcyclodextrin (HPbCD) and hydroxypropyl-c-cyclodextrin (HPcCD)] and camphor (HPbCD/camphor-IC-NF and HPcCD/camphor-IC-NF). Although camphor is a volatile and hydrophobic essential oil component, the improvement in the aqueous solubility and thermal s...

BACKGROUND Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and extensive first-pass metabolism, the absolute bioavailability of CVD does not exceed 30%. To overcome these drawbacks, the objective of this work was to improve the solubility and onset of action of CVD thro...

Benzocaine is a local anesthetic used for different pain treatments. Including it in various cyclodextrins one can increase the solubility of this drug. Several inclusion compounds of β-cyclodextrin (β-CD) with benzocaine, prepared by kneading and coprecipitation methods, were investigated. In order to understand the inclusion process mechanisms FT IR spectroscopic investigation and molecular m...

The objectives of this study were to characterize a synthesis brom-isoflavanone (notated IF) with possible pharmacological activities, water insoluble and to examine the potential of beta-cyclodextrin to improve this property and obtain inclusion compounds that were analysed by different techniques: UV-Vis, IR, 1HNMR spectroscopy, thermal analysis. The presence of β-cyclodextrin rises the conte...

The aim was to study the ability of bioadhesive cyclodextrin-poly(anhydride) nanoparticles as carriers for the oral delivery of atovaquone (ATO). In order to increase the loading capacity of ATO by poly(anhydride) nanoparticles, the following oligosaccharides were assayed: 2-hydroxypropyl-β-cyclodextrin (HPCD), 2,6-di-O-methyl-β-cyclodextrin (DCMD), randomly methylated-β-cyclodextrin (RMCD) and...

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

Interaction of the antipsychotic drug risperidone with hydroxypropyl-beta-cyclodextrin (HPBCD) in solution and in the solid state was studied with the aim of overcoming the limitations associated with nasal administration of low solubility drugs. Risperidone solubility studies revealed inclusion complex formation with a 1:1 stoichiometry. Low concentrations (0.1 w/v %) of hydroxypropylmethyl ce...

Abstract: Introduction: Embelin, a phytoconstituent obtained from Embelia ribes of the Myrsinaceae family, has anti-cancer, anti-inflammatory, anti-bacterial, anti-fertility, analgesic, antidiabetic, anti-depressant and wound healing activities. It is hydrophobic in nature leading to low bioavailability. Aim: The present study aims improve water solubility rate dissolution Embelin by complexati...