<p>Route optimization problem using vehicle routing (VRP) and time window constraint is explained as finding paths for a finite count of vehicles to provide service huge number customers hence, optimizing the path in given duration window. The loop have restricted intake capacity. This initiates from depot, delivers goods, stops at depot. Each customer serve exactly once. If arrival befor...

Type-1 diabetes (T1D) is a metabolic disorder associated with massive reduction in mass of adipose tissue. Measuring cell diameter, an index of fat metabolism, we determined depot-specific alterations in weight of adipose tissue, fat cell diameter and size heterogeneity and distribution at 5 depots in streptozotocin (STZ)-induced diabetic rats. T1D was induced by a single injection of STZ. Seve...

OBJECTIVE To measure the effect of 24 months of depot medroxyprogesterone acetate use on bone mineral density compared with oral contraception (pills) and nonhormonal contraception. METHODS Women aged 18-33 years self-selected oral contraception, depot medroxyprogesterone acetate, or nonhormonal contraception (controls). Those selecting pills were randomized to formulations containing either ...

Peptide antigens are combined with an adjuvant in order to increase immunogenicity in vivo. The immunogenicity and safety of a RSV vaccine formulated in a novel oil-based platform, DepoVax™ (DPX), was compared to an alum formulation. A peptide B cell epitope derived from RSV small hydrophobic ectodomain (SHe) served as the antigen. Both vaccines induced SHe-specific antibodies after immunizatio...

Differences in the inherent properties of adipose tissue-derived stem cells (ASC) may contribute to the biological specificity of the subcutaneous (Sc) and visceral (V) adipose tissue depots. In this study, three distinct subpopulations of ASC, i.e. ASCSVF, ASCBottom, and ASCCeiling, were isolated from Sc and V fat biopsies of non-obese subjects, and their gene expression and functional charact...

Hormonally induced azoospermia induced by weekly im injections of testosterone enanthate provides effective and reversible male contraception, but more practical regimens are needed. Given our previous findings that six 200-mg pellets implanted subdermally produced more stable, physiological T levels and reduced the delivered T dose by more than 50% while maintaining equally effective suppressi...

Annotation. A solution to the problem of prevention and treatment prosthetic stomatitis, which occurs when using complete removable acrylic prostheses, is presented. The author proposes a modification base prosthesis in order create depot medicinal substance — amaranth oil. For clinical approval, 114 people who were divided into three groups given prostheses. Patients first group (n=22) prescri...

An “atypical” accident scenario is a scenario deviating from normal expectations and, thus, not deemed credible by common processes of risk assessment. Past experience shows that non identified accident scenarios as such represent a latent risk for industry and society and sometimes their occurrence can lead to consequences of unexpected extent. An evident example of an atypical accident was th...