BACKGROUND Multiple occurrences of oesophageal dysplasia are frequently observed in head and neck cancer patients, and closely associated with alcohol consumption. Acetaldehyde, the first metabolite of ethanol, is thought to play an important role in the carcinogenesis of the upper aerodigestive tract. AIM To investigate if genetic polymorphism in alcohol metabolising enzymes (ADH3, alcohol d...

AIM To investigate the impact of histology on outcome in advanced oesophageal cancer treated with first-line fluoropyrimidine-based chemotherapy. METHODS Individual patient data were pooled from three randomised phase III trials of fluoropyrimidine-based chemotherapy ± platinum/anthracycline in patients with advanced, untreated gastroesophageal adenocarcinoma or squamous cell carcinoma (SCC) ...

Alcohol consumption is a significant risk factor for gastrointestinal cancers that may be controlled. The of cancer increases with the amount and duration drinking. Even occasional drinking can raise risk; 100 g or less per week presently thought to upper limit low-risk consumption. causally linked colorectal cancer, hepatocellular carcinoma, gastric oesophageal squamous cell most likely also p...

Abstract Background Patients with oesophageal or gastro-oesophageal junction (GOJ) cancer that fail to respond chemoradiotherapy have a poor clinical prognosis. Recent trials investigated the use of immune checkpoint inhibitors in these patients. The programmed cell death protein 1 (PD-1) emerged as exciting therapeutic options other solid tumors, such non-small lung cancer, renal carcinoma and...

The worldwide incidence of esophageal carcinoma has been rising rapidly over the past few decades. However, in only 31% of patients the carcinoma is detected early in situ. It is essential to detect the malignancy early and to determine the extent of the disease to ensure the best option for a cure. Recent advances in endoscopic technology, including high-resolution magnification endoscopy, nar...

BACKGROUND Oesophageal carcinoma is a rare disease with often dismal prognosis. Despite multiple trials addressing specific issues, currently, many questions in management remain unanswered. This work aimed to specifically address areas in the management of oesophageal cancer where high level evidence is not available, performing trials is very demanding and for many questions high-level eviden...