نتایج جستجو برای: odorant

تعداد نتایج: 3893  

Journal: :Learning & memory 2010
Aoife Larkin Somdatta Karak Rashi Priya Abhijit Das Champakali Ayyub Kei Ito Veronica Rodrigues Mani Ramaswami

Naive Drosophila larvae show vigorous chemotaxis toward many odorants including ethyl acetate (EA). Chemotaxis toward EA is substantially reduced after a 5-min pre-exposure to the odorant and recovers with a half-time of ∼20 min. An analogous behavioral decrement can be induced without odorant-receptor activation through channelrhodopsin-based, direct photoexcitation of odorant sensory neurons ...

Journal: :Neuron 2006
Wen Li Erin Luxenberg Todd Parrish Jay A. Gottfried

It is widely presumed that odor quality is a direct outcome of odorant structure, but human studies indicate that molecular knowledge of an odorant is not always sufficient to predict odor quality. Indeed, the same olfactory input may generate different odor percepts depending on prior learning and experience. Combining functional magnetic resonance imaging with an olfactory paradigm of percept...

2015
Douglas A. Storace Oliver R. Braubach Lei Jin Lawrence B. Cohen Uhna Sung

Understanding the roles of different cell types in the behaviors generated by neural circuits requires protein indicators that report neural activity with high spatio-temporal resolution. Genetically encoded fluorescent protein (FP) voltage sensors, which optically report the electrical activity in distinct cell populations, are, in principle, ideal candidates. Here we demonstrate that the FP v...

2009
Zu Soh Ryuji Inazawa Toshio Tsuji Noboru Takiguchi Hisao Ohtake

Recently, the importance of odors has begun to be emphasized as well as methods for their evaluation, especially in the fragrance and food industries. Although odors can be characterized by their odorant components, their chemical information cannot be directly related to the flavors we perceive. Recent research has revealed that neuronal activity related to glomeruli (which form part of the ol...

Journal: :Science 2014
Lulu Tsai Gilad Barnea

The olfactory system remains plastic throughout life because of continuous neurogenesis of sensory neurons in the nose and inhibitory interneurons in the olfactory bulb. Here, we reveal that transgenic expression of an odorant receptor has non-cell autonomous effects on axons expressing this receptor from the endogenous gene. Perinatal expression of transgenic odorant receptor causes rerouting ...

Journal: :Neuron 2005
Dana M. Small Johannes C. Gerber Y. Erica Mak Thomas Hummel

Odors perceived through the mouth (retronasally) as flavor are referred to the oral cavity, whereas odors perceived through the nose (orthonasally) are referred to the external world. We delivered vaporized odorants via the orthonasal and retronasal routes and measured brain response with fMRI. Comparison of retronasal versus orthonasal delivery produced preferential activity in the mouth area ...

Journal: :Neuron 1999
Benjamin D. Rubin Lawrence C. Katz

We adapted the technique of intrinsic signal imaging to visualize how odorant concentration and structure are represented spatially in the rat olfactory bulb. Most odorants activated one or more glomeruli in the imaged region of the bulb; these optically imaged responses reflected the excitation of underlying neurons. Odorant-evoked patterns were similar across animals and symmetrical in the tw...

Journal: :Chemical senses 2001
H Yamada K Nakatani

Although many studies have reported that odorants can elicit inhibitory responses as well as excitatory responses in vertebrate olfactory receptor neurons, the cellular mechanisms that underlie this inhibition are unclear. Here we examine the inhibitory effect of odorants on newt olfactory receptor neurons using whole cell patch clamp recording. At high concentrations, odorant stimulation decre...

Journal: :Advanced materials 2011
Adem Yildirim Mert Vural Mecit Yaman Mehmet Bayindir

IO N The mammalian olfactory system uses about four hundred cross-responsive receptors located at the end of olfactory neurons for exquisite detection and discrimination of tens of thousands of different odorant molecules. Each odorant, with its particular shape, size, functional group, and charge combination, induces a unique combinatorial response, or odorant code, from a library of olfactory...

Journal: :Journal of neurophysiology 2009
Hadas Lapid Han-Seok Seo Benno Schuster Elad Schneidman Yehudah Roth David Harel Noam Sobel Thomas Hummel

Electroolfactograms (EOGs) are the summated generator potentials of olfactory receptor neurons measured directly from the olfactory epithelium. To validate the sensory origin of the human EOG, we set out to ask whether EOGs measured in humans were odorant concentration dependent. Each of 22 subjects (12 women, mean age = 23.3 yr) was tested with two odorants, either valeric acid and linalool (n...

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