نتایج جستجو برای: occludin
تعداد نتایج: 1653 فیلتر نتایج به سال:
This study investigated the effects and mechanisms of miR-132 related to permeability mobility human retinal pigment epithelium ARPE-19 cells in high-glucose (HG) condition. were cultured normal HG condition identified by immunofluorescence staining. Cell viability was assessed MTT assay, cell FITC-dextran assay wound healing assay. Different miRNA mRNA expression levels determined quantitative...
Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta)...
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support the model in which HCV enters liver ce...
In epithelial and endothelial cells, the tight junction (TJ) seals cells to create a primary barrier to the diffusion of solutes across the cell sheet, and it also works as a boundary between the apical and basolateral membrane domains to create their polarization. An integral membrane protein working at TJ is postulated to exist, but it has remained elusive for quite some time. Most recently, ...
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