We report two cases of liver metastases from colorectal and anal cancers after the failure systemic chemotherapies that were successfully treated with a combination therapy transarterial chemoembolization using irinotecan-loaded drug-eluting beads hepatic arterial infusion chemotherapy. In both cases, chemotherapy was performed as maintenance beads. Irinotecan at dose 120 mg loaded on drug deli...

Background. Tuberculosis is a major public health problem in South Africa, made worse by poor adherence to and frequent interruption of treatment. Direct observation (DO) of tuberculosis patients taking their drugs is supposed to improve treatment completion and outcome. We compared DO with self-supervision, in which patients on the same drug regimen are not observed taking their pills, to asse...

This paper evaluates procedures relevant to extrapolating from toxicity data in man and animals to Occupational Exposure Limits. It examines effects at or around the "No Observed Adverse Effect Level' (NOAEL) and the magnitude of safety factors which can be applied in developing occupational exposure limits for non-stochastic effects. The relationship between incidence of stochastic effect and ...

Our objective was to illustrate the effects of using stricter standards for the quality of evidence used in decision analytic modeling. We created a simple 10-parameter probabilistic Markov model to estimate the cost-effectiveness of directly observed therapy (DOT) for individuals with newly diagnosed HIV infection. We evaluated quality of evidence on the basis of U.S. Preventive Services Task ...

The Bayesian network (BN) is a convenient tool for probabilistic modeling of system performance, particularly when it is of interest to update the reliability of the system or its components in light of observed information. In this paper, BN structures for modeling the performance of systems that are defined in terms of their minimum link or cut sets are investigated. Standard BN structures th...