PURPOSE While obesity is associated with increased mortality and decreased functional outcomes in adult burn patients, the ramifications of larger than average body size in the pediatric burn population are less well understood. The present study examines whether obesity was associated with poor outcomes following pediatric burn injuries. METHODS Thermal injury data for patients ≤ 18 years of...

INTRODUCTION There is conflicting data as to whether obesity is an independent risk factor for mortality in severe pandemic (H1N1) 2009 influenza (A(H1N1)pdm09). It is postulated that excess inflammation and cytokine production in obese patients following severe influenza infection leads to viral pneumonitis and/or acute respiratory distress syndrome. METHODS Demographic, laboratory and clini...

The objective of this study was to analyze whether obese women with no metabolic syndrome (MetS) have increased cardiometabolic risk compared to non-obese women and to observe the correlations between adiposity and coronary heart disease (CHD) risk factors in metabolically healthy women. 20-40 year old non-obese (n=41), obese with no MetS (n=30) and obese with MetS (n=28) women were studied. Li...

OBJECTIVE The effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and are distinct from other adipose tissue depots. The purpose of this investigation was to examine the effects of lean and obese coronary PVAT on end-effector mechanisms of coronary vasodilation and to identify potential factors involved. APPROACH AND RESULTS Hematoxyli...

Objective: To evaluate differences in perinatal complications in obese vs. non-obese non-Hispanic Black and non-Hispanic White pregnant women. Study Design: A retrospective cohort analysis of perinatal outcomes in non-Hispanic Black (NHB) vs. non-Hispanic White (NHW) women who were either obese with a pre-pregnancy body mass index (BMI) ≥30 or non-obese BMI < 30. Primary outcome was cesarean de...

On the basis of the 3D structure of a bovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have developed a versatile approach for generating human or humanized antibody agonists with excellent pharmacological properties. Using human growth hormone (hGH) and human leptin (hLeptin) as model proteins, we have demonstrated that functional human antibody CDR fu...

3 Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, 8 China 9 * Corresponding author 10 Xiaodong Sun 11 Department of Endocrinology, Affiliated Hospital of Weifang Medical University, 2428 Yuhe 12 Road, Weifang, Shandong, 261031, China 13 Email: [email protected] Tel (086)18653625906 14 15 Running title: Irisin improves endothelial function 16 17 18 19 20...

According to WHO, 53.5–69.5% of adult men and 47.2–61.8% of adult women were classified as overweight in seven European countries. Among adults classified as overweight, 7.7– 26.0% of men and 9.0–21.0% of women were classified as obese (1). BMI is not always related to the degree of insulin resistance, although BMI is an important indicator for diagnosing obesity. Furthermore, a low occurrence ...

Background: According to previous studies, patient with metabolic syndrome (MetS) are different in terms of body composition from healthy subjects. The purpose of the present study was to determine the body composition of healthy obese/overweight patients and compared them with those having MetS. Methods: A case-control study was conducted on both men and women aged 20 to 55 years, who were sel...