Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier permeability of drug candidates. Moreover, halogenation of aromatic molecules greatly affects aromatic interaction-mediated self-assembly processes, including amyloid fibril formation. Perturbation of the aromatic interacti...

The abnormal aggregation of β-amyloid (Aβ) peptides in the brain is a major pathological hallmark of Alzheimer's disease (AD). The suppression (or alteration) of Aβ aggregation is considered to be an attractive therapeutic intervention for treating AD. We report on visible light-induced inhibition of Aβ aggregation by xanthene dyes, which are widely used as biomolecule tracers and imaging marke...

To control the molecular organization of octadecyl rhodamine B (RhB18), hybrid Langmuir–Blodgett monolayers containing clay minerals were prepared. The orientation and conformation of the RhB18 molecule were analyzed by polarized attenuated total reflection Fourier transform infrared (ATR–FTIR) spectroscopy and fluorescence spectroscopy. Monomers and dimers of RhB18 were observed by UV-Vis abso...

The title compound, C(28)H(30)N(2)O(3)·C(9)H(10)O(5), is a well known red leuco complex of 2-(6-diethylamino-3-diethyl-iminio-3H-xanthen-9-yl)benzoate (rhodamine B base abbreviated to RBB, a leuco dye) with ethyl gallate (EG, developer). The structure of the complex at room temperature has recently been reported by Sekiguchi, Takayama, Gotanda & Sano [Chem. Lett. (2007 ▶), 36, 1010-1011]. We ha...